Ascending aortic dissection in a young patient using a synephrine-containing workout supplement.

Aortic dissection in young patients presents a clinical and diagnostic challenge. Atypical symptoms of ascending aortic dissection can delay presentation and diagnosis. Here, we describe a patient with delayed diagnosis of an atypical presentation of ascending aortic dissection after using a synephrine-containing pre-workout supplement. The diagnosis was initially missed on computed tomography, but subsequently made on echocardiography. This is the first reported case of ascending aortic dissection in the setting of synephrine supplementation. This case illustrates a potential cardiovascular adverse effect of synephrine and highlights the need for clinical trials without conflicts of interest assessing its safety. <Learning objective: The aims of this report are to highlight the diagnostic challenge of an atypical presentation of ascending aortic dissection and to illustrate a potential cardiovascular adverse effect of synephrine supplementation.>.