Does the plasma refilling coefficient change during hemodialysis sessions?

The filtration coefficient in the Starling equation is an important determinant of plasma refilling during hemodialysis. A method for calculating from clinical data an estimate of the filtration coefficient, called the refilling coefficient, was proposed in the past. The assumption behind this method was that the only drive for refilling is the increase in plasma oncotic pressure, and the remaining Starling forces have negligible effect. The refilling coefficient was observed to decrease during hemodialysis, and this was interpreted as a change in the filtration coefficient. The purpose of our study was providing an alternative explanation for the behavior of the refilling coefficient and, using clinical data and mathematical modeling, to predict the values of the immeasurable Starling forces and provide the theoretical basis for the interpretation of the refilling coefficient as the filtration coefficient. Blood volume and bioimpedance data from 23 patients undergoing hemodialysis were used to calculate the refilling coefficient according to the original formulation and to fit a two-compartment model of protein and fluid transport. The changes in the other Starling forces were non-negligible, ranging from 19% to 60% of plasma oncotic pressure. The results showed that the decrease observed in the refilling coefficient is likely caused by neglecting important changes in the Starling forces while deriving the equation for the refilling coefficient. When these Starling forces were taken into account, constant filtration coefficient and dynamic refilling coefficient provided an equivalent description of the data in most cases. However, this was not true for a subgroup of sessions, which suggests that additional factors may also be responsible for the observed decrease in the refilling coefficient.