Laurence Bigay-Gamé1, Suzanna Bota2, Laurent Greillier3, Isabelle Monnet4, Anne Madroszyk5, Romain Corre6, Bénédicte Mastroianni7, Lionel Falchero8, Julien Mazières9, Hélène Colineaux9, Benoit Lepage9, Christos Chouaid4. 1. Centre Hospitalier Universitaire Toulouse, Toulouse, Francebigaygame.l@chu-toulouse.fr. 2. Centre Hospitalier Universitaire de Rouen, Rouen, France. 3. Assistance Publique - Hôpitaux de Marseille, Aix Marseille University, Marseille, France. 4. Centre Hospitalier Intercommunal de Créteil, Créteil, France. 5. Institut Paoli Calmettes, Marseille, France. 6. Centre Hospitalier Universitaire de Rennes, Rennes, France. 7. Hospices Civils de Lyon, Lyon, France. 8. Hôpital Nord-Ouest, Villefranche Sur Saône, France. 9. Centre Hospitalier Universitaire Toulouse, Toulouse, France.
Abstract
OBJECTIVES: The aim of this study was to describe the demographic and clinico-pathological characteristics of lung cancer in patients younger than 40 years. MATERIALS AND METHODS: This was a prospective study performed within the Groupe Français de Pneumo-Cancérologie. Consecutive patients diagnosed with lung cancer before the age of 40 years were eligible. Data on demographics, medical history, clinico-pathological characteristics, treatment and overall survival were analysed. RESULTS: In total, 146 patients were included from January 2011 to December 2013. Median age was 38 years (IQR: 34-40). Women accounted for 41%. Main histological type was adenocarcinoma (77%). Only 3% had a prior history of cancer, but a family history (first- or second-degree relatives) of cancer was reported in 80 (55%) patients; 85 and 50% were current or past smokers of tobacco and cannabis, respectively; 82% had stage IIIB/IV at diagnosis. Median overall survival was 15.3 (95% CI: 8.1-24.0) months in the whole population, 10.3 (95% CI: 12.5-14.2) months in stage IV and 15 (95% CI: 8.7-35.2) months in stage III. One- and two-year overall survival rates were 57% (95 CI: 49-65) and 31.5% (95 CI: 27-43), respectively. Compared to smokers, non-smokers were significantly younger and more often females. Median overall survival was not statistically different between smokers and non-smokers.
OBJECTIVES: The aim of this study was to describe the demographic and clinico-pathological characteristics of lung cancer in patients younger than 40 years. MATERIALS AND METHODS: This was a prospective study performed within the Groupe Français de Pneumo-Cancérologie. Consecutive patients diagnosed with lung cancer before the age of 40 years were eligible. Data on demographics, medical history, clinico-pathological characteristics, treatment and overall survival were analysed. RESULTS: In total, 146 patients were included from January 2011 to December 2013. Median age was 38 years (IQR: 34-40). Women accounted for 41%. Main histological type was adenocarcinoma (77%). Only 3% had a prior history of cancer, but a family history (first- or second-degree relatives) of cancer was reported in 80 (55%) patients; 85 and 50% were current or past smokers of tobacco and cannabis, respectively; 82% had stage IIIB/IV at diagnosis. Median overall survival was 15.3 (95% CI: 8.1-24.0) months in the whole population, 10.3 (95% CI: 12.5-14.2) months in stage IV and 15 (95% CI: 8.7-35.2) months in stage III. One- and two-year overall survival rates were 57% (95 CI: 49-65) and 31.5% (95 CI: 27-43), respectively. Compared to smokers, non-smokers were significantly younger and more often females. Median overall survival was not statistically different between smokers and non-smokers.
Authors: Sarah Cullivan; Sarah Ni Mhaolcatha; Michael T Henry; Nazri Kaderi Muhammad; William Mullally; Richard M Bambury; Louise Burke; Marcus P Kennedy Journal: Transl Cancer Res Date: 2019-08 Impact factor: 1.241