Mengyin Wu1, Xianlei Cai2, Jingjing Lin1, Xinhan Zhang1, E Marian Scott3, Xiuyang Li4. 1. Department of Epidemiology & Biostatistics, Zhejiang University, Hangzhou, China. 2. Department of Gastrointestinal Surgery, Ningbo Medical Center Lihuili Hospital, Ningbo, China. 3. Department of Mathematics and Statistics, University of Glasgow, Glasgow, UK. Electronic address: Marian.Scott@glasgow.ac.uk. 4. Department of Epidemiology & Biostatistics, Zhejiang University, Hangzhou, China. Electronic address: lixiuyang@zju.edu.cn.
Abstract
BACKGROUND AND OBJECTIVE: Indoxyl sulphate (IS) and p-cresyl sulphate (PCS), which are difficult to excrete adequately out of the body, are closely related to the progression of chronic kidney disease (CKD) and various deuteropathy. Better than peritoneal dialysis (PD) and haemodialysis (HD), dietary fibre has been considered to reduce IS and PCS levels. In view of the absence of formal recommendations on fibre intake in CKD nutritional guidelines, we conducted this meta-analysis to assess the effects of dietary fibre on IS and PCS for CKD patients. METHODS: The effects were pooled and expressed in terms of weighted mean difference (WMD) with 95% confidence interval (95% CI). Q test and I2 statistics were used to assess the heterogeneity. RESULTS: A total of 12 relevant estimates from 7 reports, including 203 CKD patients, showed that dietary fibre significantly reduced their PCS level (WMD = -16.160, 95% CI: -23.824, -8.495). CONCLUSIONS: The meta-analysis produced a strong corroboration that dietary fibre intake does have a good therapeutic effect on patients with CKD. The conclusions need to be validated by randomised controlled experiments (RCT) with better design, larger samples, longer course of treatment and higher quality.
BACKGROUND AND OBJECTIVE:Indoxyl sulphate (IS) and p-cresyl sulphate (PCS), which are difficult to excrete adequately out of the body, are closely related to the progression of chronic kidney disease (CKD) and various deuteropathy. Better than peritoneal dialysis (PD) and haemodialysis (HD), dietary fibre has been considered to reduce IS and PCS levels. In view of the absence of formal recommendations on fibre intake in CKD nutritional guidelines, we conducted this meta-analysis to assess the effects of dietary fibre on IS and PCS for CKDpatients. METHODS: The effects were pooled and expressed in terms of weighted mean difference (WMD) with 95% confidence interval (95% CI). Q test and I2 statistics were used to assess the heterogeneity. RESULTS: A total of 12 relevant estimates from 7 reports, including 203 CKDpatients, showed that dietary fibre significantly reduced their PCS level (WMD = -16.160, 95% CI: -23.824, -8.495). CONCLUSIONS: The meta-analysis produced a strong corroboration that dietary fibre intake does have a good therapeutic effect on patients with CKD. The conclusions need to be validated by randomised controlled experiments (RCT) with better design, larger samples, longer course of treatment and higher quality.
Authors: Guobin Su; Xindong Qin; Changyuan Yang; Alice Sabatino; Jaimon T Kelly; Carla Maria Avesani; Juan Jesus Carrero Journal: Clin Kidney J Date: 2021-09-14
Authors: Ann Raes; Sunny Eloot; Amina El Amouri; Evelien Snauwaert; Aurélie Foulon; Charlotte Vande Moortel; Maria Van Dyck; Koen Van Hoeck; Nathalie Godefroid; Griet Glorieux; Wim Van Biesen; Johan Vande Walle Journal: Pediatr Nephrol Date: 2021-01-02 Impact factor: 3.714
Authors: Amina El Amouri; Evelien Snauwaert; Aurélie Foulon; Charlotte Vande Moortel; Maria Van Dyck; Koen Van Hoeck; Nathalie Godefroid; Griet Glorieux; Wim Van Biesen; Johan Vande Walle; Ann Raes; Sunny Eloot Journal: Toxins (Basel) Date: 2021-03-19 Impact factor: 4.546