BACKGROUND: Previous studies have shown that type 2 diabetes (DM2) is associated with sudden cardiac death (SCD) risk in post-myocardial infarction patients. The treatment of coronary artery disease (CAD) as well as DM2 has changed over time. OBJECTIVE: The purpose of this study was to compare the incidence of SCD in DM2 and nondiabetic patients with CAD and preserved ejection fraction (EF) in a prospective observational study (ARTEMIS study). METHODS: In 834 DM2 patients and 1112 nondiabetic patients with CAD enrolled, the EF measured ≥3 months after qualifying was 63% ± 10% in DM2 patients and 65% ± 8% in nondiabetic patients (P < .01). The primary end point was SCD or resuscitation from sudden cardiac arrest (SCA). All-cause mortality, cardiac mortality, non-SCD, hospitalization for heart failure, and acute coronary syndrome were secondary end points. RESULTS: During a mean follow-up of 6.3 ± 1.6 years, SCDs/SCAs occurred in 50 patients. The prevalence of SCD/SCA was higher in DM2 patients (4.1%) than in nondiabetic patients (1.4%) (adjusted hazard ratio 2.6; 95% confidence interval 1.3-5.3; P < .01). However, the non-SCD component of cardiac mortality was not significantly different between DM2 and nondiabetic patients. In addition, heart failure hospitalizations were more common in DM2 patients (8.4%) than in nondiabetic patients (2.9%) (P < .001). The annual cardiac mortality in nondiabetic patients with CAD was 0.50%, which was lower than the 0.59% reported in the general Finnish population. CONCLUSION: DM2 is an independent risk factor for SCD/SCA in CAD patients with preserved EF. Cardiac mortality in nondiabetic CAD patients is slightly lower than that in the general population in the present treatment era.
BACKGROUND: Previous studies have shown that type 2 diabetes (DM2) is associated with sudden cardiac death (SCD) risk in post-myocardial infarctionpatients. The treatment of coronary artery disease (CAD) as well as DM2 has changed over time. OBJECTIVE: The purpose of this study was to compare the incidence of SCD in DM2 and nondiabeticpatients with CAD and preserved ejection fraction (EF) in a prospective observational study (ARTEMIS study). METHODS: In 834 DM2patients and 1112 nondiabeticpatients with CAD enrolled, the EF measured ≥3 months after qualifying was 63% ± 10% in DM2patients and 65% ± 8% in nondiabeticpatients (P < .01). The primary end point was SCD or resuscitation from sudden cardiac arrest (SCA). All-cause mortality, cardiac mortality, non-SCD, hospitalization for heart failure, and acute coronary syndrome were secondary end points. RESULTS: During a mean follow-up of 6.3 ± 1.6 years, SCDs/SCAs occurred in 50 patients. The prevalence of SCD/SCA was higher in DM2patients (4.1%) than in nondiabeticpatients (1.4%) (adjusted hazard ratio 2.6; 95% confidence interval 1.3-5.3; P < .01). However, the non-SCD component of cardiac mortality was not significantly different between DM2 and nondiabeticpatients. In addition, heart failure hospitalizations were more common in DM2patients (8.4%) than in nondiabeticpatients (2.9%) (P < .001). The annual cardiac mortality in nondiabeticpatients with CAD was 0.50%, which was lower than the 0.59% reported in the general Finnish population. CONCLUSION:DM2 is an independent risk factor for SCD/SCA in CAD patients with preserved EF. Cardiac mortality in nondiabetic CADpatients is slightly lower than that in the general population in the present treatment era.
Authors: Neal A Chatterjee; Jani T Tikkanen; Gopi K Panicker; Dhiraj Narula; Daniel C Lee; Tuomas Kentta; Juhani M Junttila; Nancy R Cook; Alan Kadish; Jeffrey J Goldberger; Heikki V Huikuri; Christine M Albert Journal: Eur Heart J Date: 2020-06-01 Impact factor: 29.983
Authors: Jenni J Hekkanen; Tuomas V Kenttä; Mira Anette E Haukilahti; Janne T Rahola; Lauri Holmström; Juha Vähätalo; Mikko P Tulppo; Antti M Kiviniemi; Lasse Pakanen; Olavi H Ukkola; M Juhani Junttila; Heikki V Huikuri; Juha S Perkiömäki Journal: Front Physiol Date: 2020-08-25 Impact factor: 4.566
Authors: Janne T Rahola; Antti M Kiviniemi; Olavi H Ukkola; Mikko P Tulppo; M Juhani Junttila; Heikki V Huikuri; Tuomas V Kenttä; Juha S Perkiömäki Journal: Ann Noninvasive Electrocardiol Date: 2021-01-23 Impact factor: 1.468
Authors: Yasamen A Shikdar; Hala H Mosli; Nasrin A Shikdar; Rajaa M Alshanketi; Noorah A Shikdar; Raghdaa M Malebary; Wedyan M Aboznadah; Mohammad A Shikdar Journal: Cureus Date: 2022-05-25
Authors: Ramkumar V Venkateswaran; M V Moorthy; Neal A Chatterjee; Julie Pester; Alan H Kadish; Daniel C Lee; Nancy R Cook; Christine M Albert Journal: JACC Clin Electrophysiol Date: 2021-07-28
Authors: Antti O Vuoti; Mikko P Tulppo; Olavi H Ukkola; M Juhani Junttila; Heikki V Huikuri; Antti M Kiviniemi; Juha S Perkiömäki Journal: PLoS One Date: 2021-07-02 Impact factor: 3.240