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Literature DB >> 3027409

Resolution of a polyomavirus-mouse hybrid replicon: release of genomic viral DNA.

Abstract

RmI is a circular chimera containing 1.03 copies of polyomavirus DNA and 1,628 base pairs of mouse DNA, joined through direct and inverted repeat sequences. It is excised from the chromosome of a transformed cell via a site-specific recombination event that is dependent on the activation of the viral gene coding for large T antigen. RmI is shown here to be highly infectious for normal mouse cells. This infectivity reflects the ability of RmI to effectively yield unit-length viral DNA via intramolecular recombination. The effectiveness with which infectious viral DNA is produced from RmI is consistent with the idea that the underlying recombination event is site specific, rather than homologous or illegitimate.

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Year: 1987 PMID： 3027409 PMCID： PMC254027 DOI： 10.1128/JVI.61.3.840-844.1987

Source DB: PubMed Journal: J Virol ISSN： 0022-538X Impact factor: 5.103

27 in total

1. A mouse embryo cell line carrying an inducible, temperature-sensitive, polyoma virus genome.

Authors: P Bourgaux; L Delbecchi; K K Yu; E Herring; D Bourgaux-Ramoisy
Journal: Virology Date: 1978-07-15 Impact factor: 3.616

2. Detection of specific sequences among DNA fragments separated by gel electrophoresis.

Authors: E M Southern
Journal: J Mol Biol Date: 1975-11-05 Impact factor: 5.469

3. Discovery of a predicted DNA knot substantiates a model for site-specific recombination.

Authors: S A Wasserman; J M Dungan; N R Cozzarelli
Journal: Science Date: 1985-07-12 Impact factor: 47.728

4. An excision event that may depend on patchy homology for site specificity.

Authors: D Bourgaux-Ramoisy; D Gendron; P Chartrand; P Bourgaux
Journal: Mol Cell Biol Date: 1986-07 Impact factor: 4.272

5. Selective extraction of polyoma DNA from infected mouse cell cultures.

Authors: B Hirt
Journal: J Mol Biol Date: 1967-06-14 Impact factor: 5.469

6. The minimum amount of homology required for homologous recombination in mammalian cells.

Authors: J Rubnitz; S Subramani
Journal: Mol Cell Biol Date: 1984-11 Impact factor: 4.272

7. The temperature-sensitive defect in polyoma virus P155 mutant.

Authors: C Galup; E Herring-Gillam; B S Sylla; P Bourgaux
Journal: Virus Res Date: 1984-09 Impact factor: 3.303

8. Resolution of a polyomavirus-mouse hybrid replicon: viral function required for recombination.

Authors: A Piché; P Bourgaux
Journal: J Virol Date: 1987-03 Impact factor: 5.103

9. Alternative excision products originating from a single integration of polyomavirus DNA.

Authors: D Huberdeau; B S Sylla; E Herring-Gillam; D Bourgaux-Ramoisy; P Bourgaux
Journal: Mol Cell Biol Date: 1985-10 Impact factor: 4.272

10. Loss of integrated viral DNA sequences in polyomatransformed cells is associated with an active viral A function.

Authors: C Basilico; S Gattoni; D Zouzias; G D Valle
Journal: Cell Date: 1979-07 Impact factor: 41.582

9 in total

1. DNA nicking favors PCR recombination.

Authors: A Marton; L Delbecchi; P Bourgaux
Journal: Nucleic Acids Res Date: 1991-05-11 Impact factor: 16.971

2. Intramolecular recombination in polyomavirus DNA is a nonconservative process directed from the viral intergenic region.

Authors: C Nault; A Fricker; L Delbecchi; D Bourgaux-Ramoisy; P Bourgaux
Journal: J Virol Date: 1994-09 Impact factor: 5.103

Resolution of a polyomavirus-mouse hybrid replicon: release of genomic viral DNA.

1. A mouse embryo cell line carrying an inducible, temperature-sensitive, polyoma virus genome.

2. Detection of specific sequences among DNA fragments separated by gel electrophoresis.

3. Discovery of a predicted DNA knot substantiates a model for site-specific recombination.

4. An excision event that may depend on patchy homology for site specificity.

5. Selective extraction of polyoma DNA from infected mouse cell cultures.

6. The minimum amount of homology required for homologous recombination in mammalian cells.

7. The temperature-sensitive defect in polyoma virus P155 mutant.

8. Resolution of a polyomavirus-mouse hybrid replicon: viral function required for recombination.

9. Alternative excision products originating from a single integration of polyomavirus DNA.

10. Loss of integrated viral DNA sequences in polyomatransformed cells is associated with an active viral A function.

1. DNA nicking favors PCR recombination.

2. Intramolecular recombination in polyomavirus DNA is a nonconservative process directed from the viral intergenic region.

3. Resolution of a polyomavirus-mouse hybrid replicon: viral function required for recombination.

4. An enhancer of recombination in polyomavirus DNA.

5. Preferred crossover sites on polyomavirus DNA.

6. cis-active elements from mouse chromosomal DNA suppress simian virus 40 DNA replication.

7. Alternative homologous and nonhomologous products arising from intramolecular recombination.

8. Intramolecular recombination in polyomavirus DNA is controlled by promoter elements.

9. Crossover site selection during recombination of polyomavirus replicons.