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Literature DB >> 30273713

Review: In vitro generation of red blood cells for transfusion medicine: Progress, prospects and challenges.

Esmond Lee¹, Jaichandran Sivalingam², Zhong Ri Lim³, Gloryn Chia³, Low Gin Shi⁴, Mackenna Roberts⁵, Yuin-Han Loh⁶, Shaul Reuveny³, Steve Kah-Weng Oh³.

Abstract

In vitro generation of red blood cells (RBCs) has the potential to circumvent the shortfalls in global demand for blood for transfusion applications. The conventional approach for RBC generation has been from differentiation of hematopoietic stem cells (HSCs) derived from cord blood, adult bone marrow or peripheral blood. More recently, RBCs have been generated from human induced pluripotent stem cells (hiPSCs) as well as from immortalized adult erythroid progenitors. In this review, we highlight the recent advances to RBC generation from these different approaches and discuss the challenges and new strategies that can potentially make large-scale in vitro generation of RBCs a feasible approach.

Entities: Species

Keywords: Cord blood; Erythroid; Hematopoietic; Immortalized; Induced pluripotent stem cells; Red blood cells

Mesh：

Year: 2018 PMID： 30273713 DOI： 10.1016/j.biotechadv.2018.09.006

Source DB: PubMed Journal: Biotechnol Adv ISSN： 0734-9750 Impact factor: 14.227

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Cited

8 in total

1. Sequential cellular niches control the generation of enucleated erythrocytes from human pluripotent stem cells.

Authors: Jun Shen; Yaoyao Zhu; Cuicui Lyu; Zicen Feng; Shuzhen Lyu; Yuping Zhao; Dixie L Hoyle; Guangzhen Ji; Weimin Miao; Xiaobing Zhang; Linzhao Cheng; Robert A Brodsky; Tao Cheng; Zack Z Wang
Journal: Haematologica Date: 2020-01-31 Impact factor: 9.941

2. Single-cell transcriptomic analysis identifies an immune-prone population in erythroid precursors during human ontogenesis.

Authors: Changlu Xu; Jian He; Hongtao Wang; Yingnan Zhang; Jing Wu; Lu Zhao; Yue Li; Jie Gao; Guangfeng Geng; Bingrui Wang; Xiaoyuan Chen; Zhaofeng Zheng; Biao Shen; Yang Zeng; Zhijie Bai; Hua Yang; Shujuan Shi; Fang Dong; Shihui Ma; Erlie Jiang; Tao Cheng; Yu Lan; Jiaxi Zhou; Bing Liu; Lihong Shi
Journal: Nat Immunol Date: 2022-06-27 Impact factor: 31.250

3. Transforming growth factor β1 accelerates and enhances in vitro red blood cell formation from hematopoietic stem cells by stimulating mitophagy.

Authors: Rutuja Kuhikar; Nikhat Khan; Joseph Philip; Sameer Melinkeri; Vaijayanti Kale; Lalita Limaye
Journal: Stem Cell Res Ther Date: 2020-02-19 Impact factor: 6.832

Review: In vitro generation of red blood cells for transfusion medicine: Progress, prospects and challenges.

1. Sequential cellular niches control the generation of enucleated erythrocytes from human pluripotent stem cells.

2. Single-cell transcriptomic analysis identifies an immune-prone population in erythroid precursors during human ontogenesis.

3. Transforming growth factor β1 accelerates and enhances in vitro red blood cell formation from hematopoietic stem cells by stimulating mitophagy.

4. BMI1 enables extensive expansion of functional erythroblasts from human peripheral blood mononuclear cells.

5. Erythroid Differentiation of Induced Pluripotent Stem Cells Co-cultured with OP9 Cells for Diagnostic Purposes.

6. Membrane Properties of Human Induced Pluripotent Stem Cell-Derived Cultured Red Blood Cells.

7. In Vitro Generation of Red Blood Cells from Stem Cell and Targeted Therapy.

Review 8. Therapeutic use of red blood cells and platelets derived from human cord blood stem cells.