Qi Zhang1, Lijin Ji1, Hangping Zheng1, Qingchun Li2, Qian Xiong2, Wanwan Sun1, Xiaoming Zhu1, Yiming Li1, Bin Lu1, Xiaoxia Liu3, Shuo Zhang4. 1. Department of Endocrinology and Metabolism, Huashan Hospital, Fudan University, Shanghai 200040, China. 2. Jing'an District Center Hospital of Shanghai, Fudan University, Shanghai 200040, China. 3. Department of Endocrinology and Metabolism, Huashan Hospital, Fudan University, Shanghai 200040, China. Electronic address: xia1119@hotmail.com. 4. Department of Endocrinology and Metabolism, Huashan Hospital, Fudan University, Shanghai 200040, China. Electronic address: zhangshuo@huashan.org.cn.
Abstract
AIMS: To determine the relationship of serum phosphate, serum magnesium and peripheral nerve function in patients with type 2 diabetes mellitus (T2DM). METHODS: A total of 254 patients diagnosed with T2DM were included. Peripheral nerve function was evaluated by nerve conduction study with the use of electromyography. Composite z scores of conduction velocity, latency, and amplitude were constructed, respectively. Demographic, medical and laboratory data including serum phosphate and magnesium were collected. RESULTS: Serum phosphate and serum magnesium levels were significantly lower in patients with diabetic peripheral neuropathy (DPN) (P < 0.01). And the percentages of DPN patients were lower in high tertile of serum phosphate and serum magnesium (P < 0.05). Furthermore, composite z score of conduction velocity (CV) (P = 0.012) were positively associated with serum phosphate levels and the composite z score of amplitude (P < 0.001) and CV (P = 0.041) were positively associated with serum magnesium levels. After adjusting potential related factors (age, gender, smoking, diabetes duration, body mass index, systolic blood pressure, glycated hemoglobin, total cholesterol, estimated glomerular filtration rate), serum levels of phosphate and magnesium were still related to status of DPN in logistic regression (P < 0.05). CONCLUSION: Lower serum phosphate and magnesium significantly correlated with parameters of nerve conduction in T2DM patients. Serum phosphate and magnesium might underlie the pathophysiologic features of DPN.
AIMS: To determine the relationship of serum phosphate, serum magnesium and peripheral nerve function in patients with type 2 diabetes mellitus (T2DM). METHODS: A total of 254 patients diagnosed with T2DM were included. Peripheral nerve function was evaluated by nerve conduction study with the use of electromyography. Composite z scores of conduction velocity, latency, and amplitude were constructed, respectively. Demographic, medical and laboratory data including serum phosphate and magnesium were collected. RESULTS: Serum phosphate and serum magnesium levels were significantly lower in patients with diabetic peripheral neuropathy (DPN) (P < 0.01). And the percentages of DPNpatients were lower in high tertile of serum phosphate and serum magnesium (P < 0.05). Furthermore, composite z score of conduction velocity (CV) (P = 0.012) were positively associated with serum phosphate levels and the composite z score of amplitude (P < 0.001) and CV (P = 0.041) were positively associated with serum magnesium levels. After adjusting potential related factors (age, gender, smoking, diabetes duration, body mass index, systolic blood pressure, glycated hemoglobin, total cholesterol, estimated glomerular filtration rate), serum levels of phosphate and magnesium were still related to status of DPN in logistic regression (P < 0.05). CONCLUSION: Lower serum phosphate and magnesium significantly correlated with parameters of nerve conduction in T2DM patients. Serum phosphate and magnesium might underlie the pathophysiologic features of DPN.
Authors: Alexander Strom; Klaus Strassburger; Martin Schmuck; Hanna Shevalye; Eric Davidson; Fariba Zivehe; Gidon Bönhof; Rudolph Reimer; Bengt-Frederik Belgardt; Thomas Fleming; Barbara Biermann; Volker Burkart; Karsten Müssig; Julia Szendroedi; Mark A Yorek; Ellen Fritsche; Peter P Nawroth; Michael Roden; Dan Ziegler Journal: Mol Metab Date: 2020-11-06 Impact factor: 7.422