Gianluca Giannarini1, Rossano Girometti2, Alessandro Crestani1, Marta Rossanese3, Mattia Calandriello1, Lorenzo Cereser2, Sandra Bednarova2, Claudio Battistella4, Stefano Sioletic5, Chiara Zuiani2, Claudio Valotto1, Vincenzo Ficarra6. 1. Urology Unit, Academic Medical Centre "Santa Maria della Misericordia", Udine, Italy. 2. Department of Medicine, Institute of Radiology, University of Udine, Udine, Italy. 3. Department of Human and Paediatric Pathology "Gaetano Barresi", Urologic Section, University of Messina, Messina, Italy. 4. Department of Medicine, University of Udine, Udine, Italy. 5. Pathology Unit, Academic Medical Centre "Santa Maria della Misericordia", Udine, Italy. 6. Department of Human and Paediatric Pathology "Gaetano Barresi", Urologic Section, University of Messina, Messina, Italy. Electronic address: vficarra@unime.it.
Abstract
OBJECTIVE: To assess the accuracy of Prostate Imaging Reporting and Data System version 2 (PI-RADS v2) in detecting clinically significant prostate cancer (csPCa) on multiparametric magnetic resonance imaging (mpMRI) using whole-mount sections after radical prostatectomy (RP) as reference standard. METHODS: Forty-eight patients undergoing mpMRI before RP were prospectively enrolled. Two experienced radiologists independently scored and mapped imaging findings according to PI-RADS v2. One experienced uropathologist mapped cancers detected on whole-mount sections using the PI-RADS v2 sector scheme. Per-lesion and per-patient analyses were run. Primary outcomes were sensitivity and false discovery rate (FDR) in detecting csPCa using PI-RADS v2 score ≥3 and ≥4 as thresholds. Secondary outcome was inter-reader agreement. RESULTS: On the per-lesion analysis, sensitivity and FDR at the PI-RADS v2 threshold score ≥3 were 0.75 and 0.17 for Reader 1, and 0.67 and 0.13 for Reader 2, respectively. At the PI-RADS v2 threshold score ≥4, sensitivity was slightly lower, and FDR nearly halved for both readers. On the per-patient analysis, sensitivity for csPCa at the PI-RADS v2 threshold score ≥3 was 0.85 for Reader 1, and 0.78 for Reader 2. At the PI-RADS v2 threshold score ≥4, sensitivity was slightly lower for both readers. Inter-reader agreement was substantial (k 0.72 and 0.65 for PI-RADS v2 threshold score ≥3 and ≥4, respectively). CONCLUSION: In our prospective study with pathology after RP as standard of reference, PI-RADS v2 showed good sensitivity in detecting csPCa on mpMRI with substantial agreement between 2 experienced readers. Threshold score ≥4 had lower FDR.
OBJECTIVE: To assess the accuracy of Prostate Imaging Reporting and Data System version 2 (PI-RADS v2) in detecting clinically significant prostate cancer (csPCa) on multiparametric magnetic resonance imaging (mpMRI) using whole-mount sections after radical prostatectomy (RP) as reference standard. METHODS: Forty-eight patients undergoing mpMRI before RP were prospectively enrolled. Two experienced radiologists independently scored and mapped imaging findings according to PI-RADS v2. One experienced uropathologist mapped cancers detected on whole-mount sections using the PI-RADS v2 sector scheme. Per-lesion and per-patient analyses were run. Primary outcomes were sensitivity and false discovery rate (FDR) in detecting csPCa using PI-RADS v2 score ≥3 and ≥4 as thresholds. Secondary outcome was inter-reader agreement. RESULTS: On the per-lesion analysis, sensitivity and FDR at the PI-RADS v2 threshold score ≥3 were 0.75 and 0.17 for Reader 1, and 0.67 and 0.13 for Reader 2, respectively. At the PI-RADS v2 threshold score ≥4, sensitivity was slightly lower, and FDR nearly halved for both readers. On the per-patient analysis, sensitivity for csPCa at the PI-RADS v2 threshold score ≥3 was 0.85 for Reader 1, and 0.78 for Reader 2. At the PI-RADS v2 threshold score ≥4, sensitivity was slightly lower for both readers. Inter-reader agreement was substantial (k 0.72 and 0.65 for PI-RADS v2 threshold score ≥3 and ≥4, respectively). CONCLUSION: In our prospective study with pathology after RP as standard of reference, PI-RADS v2 showed good sensitivity in detecting csPCa on mpMRI with substantial agreement between 2 experienced readers. Threshold score ≥4 had lower FDR.
Authors: E J Bass; A Pantovic; M Connor; R Gabe; A R Padhani; A Rockall; H Sokhi; H Tam; M Winkler; H U Ahmed Journal: Prostate Cancer Prostatic Dis Date: 2020-11-20 Impact factor: 5.554
Authors: Madhuri Monique Rudolph; Alexander Daniel Jacques Baur; Hannes Cash; Matthias Haas; Samy Mahjoub; Alexander Hartenstein; Charlie Alexander Hamm; Nick Lasse Beetz; Frank Konietschke; Bernd Hamm; Patrick Asbach; Tobias Penzkofer Journal: Sci Rep Date: 2020-09-29 Impact factor: 4.379