Nikolay V Manyakov1, Abigail Bangerter2, Meenakshi Chatterjee3, Luke Mason4, Seth Ness2, David Lewin2, Andrew Skalkin3, Matthew Boice2, Matthew S Goodwin5, Geraldine Dawson6, Robert Hendren7, Bennett Leventhal8, Frederick Shic9, Gahan Pandina2. 1. Janssen Research & Development, Turnhoutseweg 30, Beerse, 2340, Belgium. 2. Janssen Research & Development, LLC, 1125 Trenton-Harbourton Road, Titusville, New Jersey, 08560. 3. Janssen Research & Development, LLC, PO Box 776, Welsh & McKean Roads, Spring House, Pennsylvania, 19477-0776. 4. Centre for Brain and Cognitive Development, Birkbeck, University of London, Malet Street WC1E 7HX, London, United Kingdom. 5. 312E Robinson Hall, Department of Health Sciences, Bouvé College of Health Sciences, Northeastern University, 360 Huntington Avenue, Boston, Massachusetts, 02115. 6. Duke Center for Autism and Brain Development, Duke University School of Medicine, 2608 Erwin Road, Suite 30, Durham, North Carolina, 27705. 7. Center for Child Health, Behavior and Development, Seattle Children's Research Institute, Department of Pediatrics, University of Washington, 2001 8th Ave Suite #400, Seattle, Washington, 98121. 8. Benioff Children's Hospital, University of California, San Francisco, 401 Parnassus Ave, Langley Porter, San Francisco, California, 94143-0984. 9. Center for Child Health, Behavior and Development, Seattle Children's Research Institute, Department of Pediatrics, University of Washington, Seattle, Washington.
Abstract
Eye-tracking studies have demonstrated that individuals with autism spectrum disorder sometimes show differences in attention and gaze patterns. This includes preference for certain nonsocial objects, heightened attention to detail, and more difficulty with attention shifting and disengagement, which may be associated with restricted and repetitive behaviors. This study utilized a visual exploration task and replicates findings of reduced number of objects explored and increased fixation duration on high autism interest objects in a large sample of individuals with autism spectrum disorder (n = 129, age 6-54 years) in comparison with a typically developing group. These findings correlated with parent-reported repetitive behaviors. Additionally, we applied recurrent quantification analysis to enable identification of new eye-tracking features, which accounted for temporal and spatial differences in viewing patterns. These new features were found to discriminate between autism spectrum disorder and typically developing groups and were correlated with parent-reported repetitive behaviors. Original and novel eye-tracking features identified by recurrent quantification analysis differed in their relationships to reported behaviors and were dependent on age. Trial Registration: NCT02299700. Autism Research 2018, 11: 1554-1566.
Eye-tracking studies have demonstrated that individuals with autism spectrum disorder sometimes show differences in attention and gaze patterns. This includes preference for certain nonsocial objects, heightened attention to detail, and more difficulty with attention shifting and disengagement, which may be associated with restricted and repetitive behaviors. This study utilized a visual exploration task and replicates findings of reduced number of objects explored and increased fixation duration on high autism interest objects in a large sample of individuals with autism spectrum disorder (n = 129, age 6-54 years) in comparison with a typically developing group. These findings correlated with parent-reported repetitive behaviors. Additionally, we applied recurrent quantification analysis to enable identification of new eye-tracking features, which accounted for temporal and spatial differences in viewing patterns. These new features were found to discriminate between autism spectrum disorder and typically developing groups and were correlated with parent-reported repetitive behaviors. Original and novel eye-tracking features identified by recurrent quantification analysis differed in their relationships to reported behaviors and were dependent on age. Trial Registration: NCT02299700. Autism Research 2018, 11: 1554-1566.
Authors: Z Ambarchi; K A Boulton; R Thapa; E E Thomas; M M DeMayo; N J Sasson; I B Hickie; Adam J Guastella Journal: J Autism Dev Disord Date: 2022-08-04
Authors: Seth L Ness; Abigail Bangerter; Nikolay V Manyakov; David Lewin; Matthew Boice; Andrew Skalkin; Shyla Jagannatha; Meenakshi Chatterjee; Geraldine Dawson; Matthew S Goodwin; Robert Hendren; Bennett Leventhal; Frederick Shic; Jean A Frazier; Yvette Janvier; Bryan H King; Judith S Miller; Christopher J Smith; Russell H Tobe; Gahan Pandina Journal: Front Neurosci Date: 2019-02-27 Impact factor: 4.677
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Authors: Dzmitry A Kaliukhovich; Nikolay V Manyakov; Abigail Bangerter; Seth Ness; Andrew Skalkin; Matthew S Goodwin; Geraldine Dawson; Robert L Hendren; Bennett Leventhal; Caitlin M Hudac; Jessica Bradshaw; Frederick Shic; Gahan Pandina Journal: Mol Autism Date: 2020-10-19 Impact factor: 7.509
Authors: Dzmitry A Kaliukhovich; Nikolay V Manyakov; Abigail Bangerter; Seth Ness; Andrew Skalkin; Matthew Boice; Matthew S Goodwin; Geraldine Dawson; Robert Hendren; Bennett Leventhal; Frederick Shic; Gahan Pandina Journal: J Autism Dev Disord Date: 2021-07
Authors: Abigail Bangerter; Meenakshi Chatterjee; Nikolay V Manyakov; Seth Ness; David Lewin; Andrew Skalkin; Matthew Boice; Matthew S Goodwin; Geraldine Dawson; Robert Hendren; Bennett Leventhal; Frederick Shic; Anna Esbensen; Gahan Pandina Journal: Front Neurosci Date: 2020-03-24 Impact factor: 4.677