Hee Sun Baek1, Man Hoon Han2, Yong Jin Kim2, Min Hyun Cho1. 1. a Department of Pediatrics, School of Medicine , Kyungpook National University , Daegu , Korea. 2. b Department of Pathology, School of Medicine , Kyungpook National University , Daegu , Korea.
Abstract
INTRODUCTION: Few studies have reported the association between the complement cascade and pediatric immunoglobulin A nephropathy (IgAN). This study aimed to investigate the association between C4d staining positivity and the clinical/histopathological characteristics of pediatric patients with IgAN. METHODS: Children diagnosed with IgAN through renal biopsy were retrospectively reviewed. Renal biopsy specimens were stained using C4d immunohistochemistry. RESULTS: Among the 56 patients, 31 (55.4%) showed positive mesangial or peripheral capillary C4d staining in glomeruli. Urine protein-to-creatinine ratio was significantly higher in C4d-positive patients (p = 0.001). The severity of mesangial proliferation according to the Haas and Oxford classification was positively associated with positive C4d staining (p < 0.001). CONCLUSION: Positive C4d staining was found to be significantly associated with the clinical/histopathological severity of IgAN.
INTRODUCTION: Few studies have reported the association between the complement cascade and pediatric immunoglobulin A nephropathy (IgAN). This study aimed to investigate the association between C4d staining positivity and the clinical/histopathological characteristics of pediatric patients with IgAN. METHODS:Children diagnosed with IgAN through renal biopsy were retrospectively reviewed. Renal biopsy specimens were stained using C4d immunohistochemistry. RESULTS: Among the 56 patients, 31 (55.4%) showed positive mesangial or peripheral capillary C4d staining in glomeruli. Urine protein-to-creatinine ratio was significantly higher in C4d-positive patients (p = 0.001). The severity of mesangial proliferation according to the Haas and Oxford classification was positively associated with positive C4d staining (p < 0.001). CONCLUSION: Positive C4d staining was found to be significantly associated with the clinical/histopathological severity of IgAN.
Entities:
Keywords:
C4d; IgA nephropathy; children; mesangial proliferation; proteinuria