Anita S Malhotra1, Poonam Goel2, Archana Chaudhary1, Suman Kochhar3, Gurjit Kaur1, Anumeha Bhagat1. 1. a Department of Physiology , Government Medical College and Hospital , Chandigarh , India. 2. b Department of Obstetrics &Gynecology , Government Medical College and Hospital , Chandigarh , India. 3. c Department of Radio diagnosis , Government Medical College and Hospital , Chandigarh , India.
Abstract
OBJECTIVE: Assessment of endothelial dysfunction for prediction of gestational hypertension/preeclampsia (GH/PE). METHODS: Serial assessment of flow-mediated vasodilatation (FMD) of brachial artery was done in first, second, and third trimesters, and within 6 weeks of delivery in primigravida (n = 654). Logistic regression was used to assess the predictive value of FMD for the development of GH/PE. RESULTS: Significant fall in FMD was observed from first trimester to third trimester but decrease in FMD in GH/PE group (57%) was more marked as compared to normal (39%) (p < 0.01). FMD (third trimester) was able to predict the development of GH/PE (OR = 1.303; 95% CI 1.088-1.562; p = 0.004). CONCLUSIONS: FMD can be used as a non-invasive marker to predict the development of GH/PE.
OBJECTIVE: Assessment of endothelial dysfunction for prediction of gestational hypertension/preeclampsia (GH/PE). METHODS: Serial assessment of flow-mediated vasodilatation (FMD) of brachial artery was done in first, second, and third trimesters, and within 6 weeks of delivery in primigravida (n = 654). Logistic regression was used to assess the predictive value of FMD for the development of GH/PE. RESULTS: Significant fall in FMD was observed from first trimester to third trimester but decrease in FMD in GH/PE group (57%) was more marked as compared to normal (39%) (p < 0.01). FMD (third trimester) was able to predict the development of GH/PE (OR = 1.303; 95% CI 1.088-1.562; p = 0.004). CONCLUSIONS:FMD can be used as a non-invasive marker to predict the development of GH/PE.
Authors: Szymon Mućka; Martyna Miodońska; Grzegorz K Jakubiak; Monika Starzak; Grzegorz Cieślar; Agata Stanek Journal: Int J Environ Res Public Health Date: 2022-09-07 Impact factor: 4.614