Heather Greenlee1,2, Danika L Lew3, Dawn L Hershman1,4, Vicky A Newman5, Lisa Hansen6, Sheri J Hartman5,7, Judith Korner4, Zaixing Shi1, Christine L Sardo Molmenti1, Antoine Sayegh8, Lou Fehrenbacher9, Shelly Lo10, Jennifer Klemp11, Kristine Rinn12, John M Robertson13, Joseph Unger3, Julie Gralow14, Kathy Albain10, Robert Krouse15, Carol Fabian11. 1. Mailman School of Public Health, Columbia University, New York, New York, USA. 2. Public Health Sciences Division, Fred Hutchinson Cancer Research Center, Seattle, Washington, USA. 3. SWOG Statistical Center, Fred Hutchinson Cancer Research Center, Seattle, Washington, USA. 4. College of Physicians and Surgeons, Columbia University, New York, New York, USA. 5. Moores Cancer Center, University of California San Diego, La Jolla, California, USA. 6. Compass Oncology, Rose Quarter Cancer Center, Portland, Oregon, USA. 7. Department of Family Medicine and Public Health, University of California San Diego, La Jolla, California, USA. 8. Kaiser Permanente NCORP/ Kaiser Permanente Roseville Medical Center, Roseville, California, USA. 9. Kaiser Permanente NCORP/Kaiser Permanente Medical Center, Vallejo, California, USA. 10. Loyola University Chicago Stritch School of Medicine, Cardinal Bernardin Cancer Center, Maywood, Illinois, USA. 11. University of Kansas Cancer Center, Westwood, Kansas, USA. 12. Puget Sound Oncology Consortium/Swedish Cancer Institute, Seattle, Washington, USA. 13. Beaumont NCORP/Beaumont Hospital, Royal Oak, Michigan, USA. 14. Seattle Cancer Care Alliance/University of Washington, Seattle, Washington, USA. 15. Corporal Michael J. Crescenz Veterans Affairs Medical Center, University of Pennsylvania, Philadelphia, Pennsylvania, USA.
Abstract
OBJECTIVE: This study aimed to test the feasibility of a 12-month weight loss intervention using telephone-based counseling plus community-situated physical activity (PA) in female breast cancer (BC) and colorectal cancer (CRC) survivors. METHODS: This multisite cooperative group study enrolled sedentary, female, postmenopausal BC and CRC survivors with BMI ≥ 25 kg/m2 to receive 12-month fitness center memberships andtelephone counseling encouraging 150 min/wk of PA and a 500-kcal/ddecrease in energy intake. Feasibility criteria included accrual, adherence, and retention. Target weight loss was ≥ 5%. RESULTS: Among 25 BC survivors, median baselineBMI was 37.2 (range: 27.7-54.6), accrual occurred in 10 months, 60% and 28% met diet and exercise goals, 80% provided 12-month measures, and average weight loss was 7.6% (95% CI: -3.9%, 19.2%). Among 23 CRC survivors, median BMI was 31.8 (range: 26.4-48.7), accrual occurred in 24 months, 61% and 17% met diet and exercise goals, 87% provided measures, and average weight loss was 2.5% (95% CI: -8.2%, 13.3%). CONCLUSIONS: It is feasible to recruit and retain BC survivors in a cooperative group diet and PA weight loss trial. BC survivors achieved clinically meaningful weight loss but did not meet a priori adherence goals. In CRC survivors, recruitment was more difficult, and the intervention was less effective.
RCT Entities:
OBJECTIVE: This study aimed to test the feasibility of a 12-month weight loss intervention using telephone-based counseling plus community-situated physical activity (PA) in female breast cancer (BC) and colorectal cancer (CRC) survivors. METHODS: This multisite cooperative group study enrolled sedentary, female, postmenopausal BC and CRC survivors with BMI ≥ 25 kg/m2 to receive 12-month fitness center memberships and telephone counseling encouraging 150 min/wk of PA and a 500-kcal/ddecrease in energy intake. Feasibility criteria included accrual, adherence, and retention. Target weight loss was ≥ 5%. RESULTS: Among 25 BC survivors, median baseline BMI was 37.2 (range: 27.7-54.6), accrual occurred in 10 months, 60% and 28% met diet and exercise goals, 80% provided 12-month measures, and average weight loss was 7.6% (95% CI: -3.9%, 19.2%). Among 23 CRC survivors, median BMI was 31.8 (range: 26.4-48.7), accrual occurred in 24 months, 61% and 17% met diet and exercise goals, 87% provided measures, and average weight loss was 2.5% (95% CI: -8.2%, 13.3%). CONCLUSIONS: It is feasible to recruit and retain BC survivors in a cooperative group diet and PA weight loss trial. BC survivors achieved clinically meaningful weight loss but did not meet a priori adherence goals. In CRC survivors, recruitment was more difficult, and the intervention was less effective.
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