| Literature DB >> 30272451 |
Vakhid A Mamedov1,2, Vera L Mamedova1,2, Saniya F Kadyrova1,2, Venera R Galimullina1, Gul'naz Z Khikmatova1,2, Dmitry E Korshin1,2, Aidar T Gubaidullin1, Dmitry B Krivolapov1, Il'dar Kh Rizvanov1, Olga B Bazanova1, Oleg G Sinyashin2, Shamil K Latypov1.
Abstract
The new efficient synthesis of biologically important 3-hydroxy-4-arylquinolin-2-ones through the Darzens condensation (epoxidation) of dichloroacetanilides with aromatic aldehydes followed by one-pot dechlorative epoxide-arene cyclization is described. This methodology has been utilized for the synthesis of naturally occurring viridicatol, a fungal metabolite isolated from the penicillium species.Entities:
Year: 2018 PMID： 30272451 DOI： 10.1021/acs.joc.8b01871
Source DB: PubMed Journal: J Org Chem ISSN： 0022-3263 Impact factor: 4.354