Literature DB >> 3027131

Localization of the gene for coagulation factor XIII a-chain to chromosome 6 and identification of sites of synthesis.

L J Weisberg, D T Shiu, C S Greenberg, Y W Kan, M A Shuman.   

Abstract

Factor XIII, the clotting factor essential for covalent stabilization of the fibrin clot, is a heterodimer consisting of a2 and b2 subunits, with catalytic function residing in the a-chain. In order to address questions regarding sites of synthesis and chromosomal localization of the Factor XIII a-chain, cDNA was cloned from a lambda gt11 human placental cDNA library. Nucleotide and amino acid sequences were determined from the cDNA. Amino acid sequencing of purified platelet Factor XIII a-chains confirmed the authenticity of the lambda gt11 clone. The gene for Factor XIII a-chain was mapped uniquely to chromosome 6. Northern blot analysis of human placental and U937 (monocytelike) cell poly (A)+ mRNA showed a single approximately 4.0-kb message for the Factor XIII a-chain. These results provide conclusive evidence that the a-chain is synthesized by placenta and monocyte cell lines.

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Year:  1987        PMID： 3027131      PMCID： PMC424157          DOI： 10.1172/JCI112862

Source DB:  PubMed          Journal:  J Clin Invest        ISSN： 0021-9738            Impact factor:   14.808


  25 in total

1.  Documentation of the plasma factor XIII deficiency in man.

Authors:  F Duckert
Journal:  Ann N Y Acad Sci       Date:  1972-12-08       Impact factor: 5.691

2.  The subunit structures of human plasma and platelet factor XIII (fibrin-stabilizing factor).

Authors:  M L Schwartz; S V Pizzo; R L Hill; P A McKee
Journal:  J Biol Chem       Date:  1971-09-25       Impact factor: 5.157

3.  The gene for coagulation factor XIII a subunit (F13A) is distal to HLA on chromosome 6.

Authors:  P G Board; M Reid; S Serjeantson
Journal:  Hum Genet       Date:  1984       Impact factor: 4.132

4.  The human insulin receptor cDNA: the structural basis for hormone-activated transmembrane signalling.

Authors:  Y Ebina; L Ellis; K Jarnagin; M Edery; L Graf; E Clauser; J H Ou; F Masiarz; Y W Kan; I D Goldfine
Journal:  Cell       Date:  1985-04       Impact factor: 41.582

5.  Identification of intracellular factor XIII in human monocytes and macrophages.

Authors:  P Henriksson; S Becker; G Lynch; J McDonagh
Journal:  J Clin Invest       Date:  1985-08       Impact factor: 14.808

6.  Efficient in vitro synthesis of biologically active RNA and RNA hybridization probes from plasmids containing a bacteriophage SP6 promoter.

Authors:  D A Melton; P A Krieg; M R Rebagliati; T Maniatis; K Zinn; M R Green
Journal:  Nucleic Acids Res       Date:  1984-09-25       Impact factor: 16.971

7.  Comparative studies on tissue transglutaminase and factor XIII.

Authors:  S I Chung
Journal:  Ann N Y Acad Sci       Date:  1972-12-08       Impact factor: 5.691

8.  High-resolution chromosome sorting and DNA spot-blot analysis assign McArdle's syndrome to chromosome 11.

Authors:  R V Lebo; F Gorin; R J Fletterick; F T Kao; M C Cheung; B D Bruce; Y W Kan
Journal:  Science       Date:  1984-07-06       Impact factor: 47.728

9.  A structural locus for coagulation factor XIIIA (F13A) is located distal to the HLA region on chromosome 6p in man.

Authors:  B Olaisen; T Gedde-Dahl; P Teisberg; E Thorsby; A Siverts; R Jonassen; M C Wilhelmy
Journal:  Am J Hum Genet       Date:  1985-01       Impact factor: 11.025

10.  Expression of platelet membrane glycoproteins and alpha-granule proteins by a human erythroleukemia cell line (HEL).

Authors:  A Tabilio; J P Rosa; U Testa; N Kieffer; A T Nurden; M C Del Canizo; J Breton-Gorius; W Vainchenker
Journal:  EMBO J       Date:  1984-02       Impact factor: 11.598
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  7 in total

1.  Deficiency of coagulation factor XIII A subunit caused by the dinucleotide deletion at the 5' end of exon III.

Authors:  T Kamura; T Okamura; M Murakawa; H Tsuda; T Teshima; T Shibuya; M Harada; Y Niho
Journal:  J Clin Invest       Date:  1992-08       Impact factor: 14.808

2.  Isolation of a fibrin-binding fragment from blood coagulation factor XIII capable of cross-linking fibrin(ogen).

Authors:  C S Greenberg; J J Enghild; A Mary; J V Dobson; K E Achyuthan
Journal:  Biochem J       Date:  1988-12-15       Impact factor: 3.857

3.  Molecular analysis of the human MHC class I region in hereditary haemochromatosis. A study by pulsed-field gel electrophoresis.

Authors:  D K Lord; I Dunham; R D Campbell; A Bomford; T Strachan; T M Cox
Journal:  Hum Genet       Date:  1990-10       Impact factor: 4.132

4.  Hemopoietic origin of factor XIII A subunits in platelets, monocytes, and plasma. Evidence from bone marrow transplantation studies.

Authors:  M C Poon; J A Russell; S Low; G D Sinclair; A R Jones; W Blahey; B A Ruether; D I Hoar
Journal:  J Clin Invest       Date:  1989-09       Impact factor: 14.808

5.  Dental Management of Factor XIII Deficiency Patients: A Case Series.

Authors:  Nanda G Pai; Lopa K Mehta; Ninad M Padhye; Zeba Mt Sayed
Journal:  Int J Clin Pediatr Dent       Date:  2020 May-Jun

6.  Haplotypes of the coagulation factor XIII A subunit locus in normal and deficient subjects.

Authors:  P G Board; R Chapple; M Coggan
Journal:  Am J Hum Genet       Date:  1988-05       Impact factor: 11.025

Review 7.  Catridecacog: a breakthrough in the treatment of congenital factor XIII A-subunit deficiency?

Authors:  Wolfgang Korte
Journal:  J Blood Med       Date:  2014-07-09
  7 in total

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