Literature DB >> 3027019

Insertions of resistance genes into Tn21-like transposons.

B Wiedemann, J F Meyer, M T Zühlsdorf.   

Abstract

The evolution of Tn21 and related multiresistance transposons of natural and artificial origin is described. Variations resulting from insertions and deletions in these transposons indicate the presence of specific recombination sites. There is evidence that these 'hot spots' are flanking several resistance genes. We examined these structures on the basis of the aadA gene, mediating resistance to spectinomycin and streptomycin. Comparison of the DNA sequences of Tn21, Tn7 and pSa indicate the wide spread of these recombination sites.

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Year:  1986        PMID： 3027019     DOI： 10.1093/jac/18.supplement_c.85

Source DB:  PubMed          Journal:  J Antimicrob Chemother        ISSN： 0305-7453            Impact factor:   5.790


  22 in total

1.  Tn21-specific structures in gram-negative bacteria from clinical isolates.

Authors:  M T Zühlsdorf; B Wiedemann
Journal:  Antimicrob Agents Chemother       Date:  1992-09       Impact factor: 5.191

2.  The chloramphenicol acetyltransferase gene of Tn2424: a new breed of cat.

Authors:  R Parent; P H Roy
Journal:  J Bacteriol       Date:  1992-05       Impact factor: 3.490

3.  Characterization of the nonenzymatic chloramphenicol resistance (cmlA) gene of the In4 integron of Tn1696: similarity of the product to transmembrane transport proteins.

Authors:  L Bissonnette; S Champetier; J P Buisson; P H Roy
Journal:  J Bacteriol       Date:  1991-07       Impact factor: 3.490

4.  The dhfrI trimethoprim resistance gene of Tn7 can be found at specific sites in other genetic surroundings.

Authors:  L Sundström; O Sköld
Journal:  Antimicrob Agents Chemother       Date:  1990-04       Impact factor: 5.191

5.  On the evolution of Tn21-like multiresistance transposons: sequence analysis of the gene (aacC1) for gentamicin acetyltransferase-3-I(AAC(3)-I), another member of the Tn21-based expression cassette.

Authors:  W Wohlleben; W Arnold; L Bissonnette; A Pelletier; A Tanguay; P H Roy; G C Gamboa; G F Barry; E Aubert; J Davies
Journal:  Mol Gen Genet       Date:  1989-06

6.  Precise insertion of antibiotic resistance determinants into Tn21-like transposons: nucleotide sequence of the OXA-1 beta-lactamase gene.

Authors:  M Ouellette; L Bissonnette; P H Roy
Journal:  Proc Natl Acad Sci U S A       Date:  1987-11       Impact factor: 11.205

7.  The region of the IncN plasmid R46 coding for resistance to beta-lactam antibiotics, streptomycin/spectinomycin and sulphonamides is closely related to antibiotic resistance segments found in IncW plasmids and in Tn21-like transposons.

Authors:  R M Hall; C Vockler
Journal:  Nucleic Acids Res       Date:  1987-09-25       Impact factor: 16.971

8.  The 3' conserved segment of integrons contains a gene associated with multidrug resistance to antiseptics and disinfectants.

Authors:  I T Paulsen; T G Littlejohn; P Rådström; L Sundström; O Sköld; G Swedberg; R A Skurray
Journal:  Antimicrob Agents Chemother       Date:  1993-04       Impact factor: 5.191

9.  A novel dihydrofolate reductase cassette inserted in an integron borne on a Tn21-like element.

Authors:  E Heikkilä; M Skurnik; L Sundström; P Huovinen
Journal:  Antimicrob Agents Chemother       Date:  1993-06       Impact factor: 5.191

10.  Analysis of genetic localization of the type I trimethoprim resistance gene from Escherichia coli isolated in Finland.

Authors:  E Heikkilä; L Sundström; M Skurnik; P Huovinen
Journal:  Antimicrob Agents Chemother       Date:  1991-08       Impact factor: 5.191
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