Victor W Zhong1, Michael P Bancks2, Pamela J Schreiner3, Cora E Lewis4, Lyn M Steffen3, James B Meigs5, Lauren A Schrader6, Melanie Schorr7, Karen K Miller7, Stephen Sidney8, Mercedes R Carnethon9. 1. Department of Preventive Medicine, Feinberg School of Medicine at Northwestern University, Chicago, IL, USA. Electronic address: wenze.zhong@northwestern.edu. 2. Department of Epidemiology & Prevention, Division of Public Health Sciences, Wake Forest School of Medicine, Winston-Salem, NC, USA. 3. Division of Epidemiology and Community Health, School of Public Health, University of Minnesota, Minneapolis, MN, USA. 4. Department of Epidemiology, School of Public Health, University of Alabama, Birmingham, AL, USA. 5. Division of General Internal Medicine, Massachusetts General Hospital, Boston, MA, USA; Department of Medicine, Harvard Medical School, Boston, MA, USA; Program in Population and Medical Genetics, Broad Institute, USA. 6. School of Medicine and Public Health, University of Wisconsin, Madison, WI, USA. 7. Neuroendocrine Unit, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA. 8. Division of Research, Kaiser Permanente Northern California, Oakland, CA, USA. 9. Department of Preventive Medicine, Feinberg School of Medicine at Northwestern University, Chicago, IL, USA.
Abstract
AIMS: To determine the association between 20-year trajectories in insulin resistance (IR) since young adulthood and appendicular lean mass (ALM) at middle-age in adults without diabetes. METHODS: A prospective cohort study was designed among young and middle-aged US men (n = 925) and women (n = 1193). Fasting serum glucose and insulin were measured five times in 1985-2005. IR was determined using the homeostasis model assessment (HOMA). ALM was measured in 2005 and ALM adjusted for BMI (ALM/BMI) was the outcome. Sex-specific analyses were performed. RESULTS: Three HOMA-IR trajectories were identified. Compared to the low-stable group, the adjusted ALM/BMI difference was -0.041 (95% CI: -0.060 to -0.022) and -0.114 (-0.141 to -0.086) in men, and -0.052 (-0.065 to -0.039) and -0.043 (-0.063 to -0.023) in women, respectively, for the medium-increase and high-increase groups. Further adjusting for the treadmill test duration attenuated these estimates to -0.022 (-0.040 to -0.004) and -0.061 (-0.089 to -0.034) in men and -0.026 (-0.038 to -0.014) and -0.007 (-0.026 to 0.012) in women. CONCLUSIONS: Compared to the low-stable insulin resistance trajectory between early and middle adulthood, the high-increase trajectory was associated with lower ALM/BMI in middle-aged men, but not women, without diabetes, after adjusting for cardiorespiratory fitness.
AIMS: To determine the association between 20-year trajectories in insulin resistance (IR) since young adulthood and appendicular lean mass (ALM) at middle-age in adults without diabetes. METHODS: A prospective cohort study was designed among young and middle-aged US men (n = 925) and women (n = 1193). Fasting serum glucose and insulin were measured five times in 1985-2005. IR was determined using the homeostasis model assessment (HOMA). ALM was measured in 2005 and ALM adjusted for BMI (ALM/BMI) was the outcome. Sex-specific analyses were performed. RESULTS: Three HOMA-IR trajectories were identified. Compared to the low-stable group, the adjusted ALM/BMI difference was -0.041 (95% CI: -0.060 to -0.022) and -0.114 (-0.141 to -0.086) in men, and -0.052 (-0.065 to -0.039) and -0.043 (-0.063 to -0.023) in women, respectively, for the medium-increase and high-increase groups. Further adjusting for the treadmill test duration attenuated these estimates to -0.022 (-0.040 to -0.004) and -0.061 (-0.089 to -0.034) in men and -0.026 (-0.038 to -0.014) and -0.007 (-0.026 to 0.012) in women. CONCLUSIONS: Compared to the low-stable insulin resistance trajectory between early and middle adulthood, the high-increase trajectory was associated with lower ALM/BMI in middle-aged men, but not women, without diabetes, after adjusting for cardiorespiratory fitness.
Authors: Mats I Nilsson; Justin P Dobson; Nicholas P Greene; Michael P Wiggs; Kevin L Shimkus; Elyse V Wudeck; Amanda R Davis; Marissa L Laureano; James D Fluckey Journal: FASEB J Date: 2013-06-26 Impact factor: 5.191
Authors: Rita R Kalyani; E Jeffrey Metter; Ramona Ramachandran; Chee W Chia; Christopher D Saudek; Luigi Ferrucci Journal: J Gerontol A Biol Sci Med Sci Date: 2011-02-24 Impact factor: 6.053
Authors: Marjolein Visser; Marco Pahor; Frances Tylavsky; Stephen B Kritchevsky; Jane A Cauley; Anne B Newman; Barbara A Blunt; Tamara B Harris Journal: J Appl Physiol (1985) Date: 2003-02-21
Authors: Joshua I Barzilay; George A Cotsonis; Jeremy Walston; Ann V Schwartz; Suzanne Satterfield; Iva Miljkovic; Tamara B Harris Journal: Diabetes Care Date: 2009-01-26 Impact factor: 19.112
Authors: Michael P Bancks; Mercedes R Carnethon; Lisa S Chow; Samuel S Gidding; David R Jacobs; Satoru Kishi; Joao Lima; Donald Lloyd-Jones; Jared P Reis; Pamela J Schreiner; Rachel Zmora; Norrina B Allen Journal: J Diabetes Complications Date: 2019-02-06 Impact factor: 3.219