Man Hin Chan1,2, Feng Wang1, Wai Kong Mang3, Lap Ah Tse1. 1. 1 JC School of Public Health and Primary Care, Chinese University of Hong Kong, Sha Tin, Hong Kong SAR, China. 2. 2 Department of Otorhinolaryngology, Head and Neck Surgery, Yan Chai Hospital, Tsuen Wan, Hong Kong SAR, China. 3. 3 Hong Kong Cancer Registry, Hong Kong, Hong Kong SAR, China.
Abstract
OBJECTIVES: : Worldwide studies have shown an increasing trend of oropharyngeal squamous cell carcinoma (OPSCC) but a decreasing trend of oral cavity cancers over the past 2 decades, particularly in developed countries with successful tobacco control. This trend has been attributed to the increase in the incidence of human papillomavirus (HPV)-associated OPSCC. The aim of this study was to examine sex differences in incidence trends of oropharyngeal and oral cavity cancers in Hong Kong from 1983 to 2014. METHODS: : Using data from the Hong Kong Cancer Registry from 1983 to 2014, age-standardized incidence rates for potentially HPV-associated sites (oropharyngeal) and non-HPV-associated sites (oral cavity) were calculated, stratified by sex and age groups. Joinpoint regression and an age-period-cohort model were used to assess incidence trends. RESULTS: : A total of 1,972 cases of oropharyngeal cancer and 7,389 cases of oral cavity cancer were diagnosed from 1983 to 2014. The male/female ratios were 4.16:1 for oropharyngeal cancers and 1.63:1 for oral cavity cancers. A significant increasing trend was observed in oropharyngeal cancers from 1994 to 2014 (average annual percentage change = 2.66, P < .05). In contrast, a significant decreasing trend was observed in oral cavity cancers from 1983 to 1994 (average annual percentage change = -5.36, P < .05). The trends were more significant in men and in patients aged 45 to 69 years. A positive birth cohort effect was observed for oropharyngeal cancer in men. CONCLUSIONS: : The rising trend of oropharyngeal cancer and decreasing trend of oral cavity cancer in Hong Kong from 1983 to 2014 are consistent with worldwide trends. Increase in high-risk sexual behaviors and oral HPV infection may influence the difference in trends.
OBJECTIVES: : Worldwide studies have shown an increasing trend of oropharyngeal squamous cell carcinoma (OPSCC) but a decreasing trend of oral cavity cancers over the past 2 decades, particularly in developed countries with successful tobacco control. This trend has been attributed to the increase in the incidence of human papillomavirus (HPV)-associated OPSCC. The aim of this study was to examine sex differences in incidence trends of oropharyngeal and oral cavity cancers in Hong Kong from 1983 to 2014. METHODS: : Using data from the Hong Kong Cancer Registry from 1983 to 2014, age-standardized incidence rates for potentially HPV-associated sites (oropharyngeal) and non-HPV-associated sites (oral cavity) were calculated, stratified by sex and age groups. Joinpoint regression and an age-period-cohort model were used to assess incidence trends. RESULTS: : A total of 1,972 cases of oropharyngeal cancer and 7,389 cases of oral cavity cancer were diagnosed from 1983 to 2014. The male/female ratios were 4.16:1 for oropharyngeal cancers and 1.63:1 for oral cavity cancers. A significant increasing trend was observed in oropharyngeal cancers from 1994 to 2014 (average annual percentage change = 2.66, P < .05). In contrast, a significant decreasing trend was observed in oral cavity cancers from 1983 to 1994 (average annual percentage change = -5.36, P < .05). The trends were more significant in men and in patients aged 45 to 69 years. A positive birth cohort effect was observed for oropharyngeal cancer in men. CONCLUSIONS: : The rising trend of oropharyngeal cancer and decreasing trend of oral cavity cancer in Hong Kong from 1983 to 2014 are consistent with worldwide trends. Increase in high-risk sexual behaviors and oral HPV infection may influence the difference in trends.
Entities:
Keywords:
HPV; cancer incidence; head and neck cancer; human papilloma virus; oral cancer; oropharyngeal cancer
Authors: Fabrício Dos Santos Menezes; Maria do Rosário Dias de Oliveira Latorre; Gleice Margarete de Souza Conceição; Maria Paula Curado; José Leopoldo Ferreira Antunes; Tatiana Natasha Toporcov Journal: PLoS One Date: 2020-05-14 Impact factor: 3.240
Authors: Rafael Cardoso Pires; Raiany Carvalho; Ricardo Ribeiro Gama; André Lopes Carvalho; Carlos Roberto Santos; Renato de Castro Capuzzo Journal: Int Arch Otorhinolaryngol Date: 2021-08-13