| Literature DB >> 30268770 |
Kannan R R Rengasamy1, Haroon Khan2, Shanmugaraj Gowrishankar3, Ricardo J L Lagoa4, Fawzi M Mahomoodally5, Ziyad Khan6, Shanoo Suroowan5, Devesh Tewari7, Gokhan Zengin8, Sherif T S Hassan9, Shunmugiah Karutha Pandian10.
Abstract
Flavonoids are natural polyphenolic compounds which are included in a panoply of drugs and used to treat and/or manage human ailments such as metabolic, cardiovascular, neurological disorders and cancer. Thus, the purpose of this review is to emphasize the importance of flavonoids for the treatment of autoimmune diseases and put into the limelight of the scientific community several health-promoting effects of flavonoids which could be beneficial for the development of novel drugs from natural products. Despite available reviews on flavonoids targeting various disease conditions, a comprehensive review of flavonoids for autoimmune diseases is still lacking. To the best of our knowledge, this is the first attempt to review the potential of flavonoids for autoimmune diseases. The structure-activity relationship of flavonoids in this review revealed that the rearrangement and introduction of other functional groups into the basic skeleton of flavonoids might lead to the development of new drugs which will be helpful in relieving the painful symptoms of various autoimmune diseases.Entities:
Keywords: Immune system; Inflammation; Medicinal plants; Multiple sclerosis; Polyphenols; Rheumatoid arthritis
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Year: 2018 PMID： 30268770 DOI： 10.1016/j.pharmthera.2018.09.009
Source DB: PubMed Journal: Pharmacol Ther ISSN： 0163-7258 Impact factor: 12.310