Elena Montecatine-Alonso1, María-Victoria Gil-Navarro1, Cecilia M Fernández-Llamazares2, Aurora Fernández-Polo3, Pere Soler-Palacín4, Jesús Llorente-Gutiérrez5, María-Teresa Gómez-Travecedo Calvo6, María-Dolores Esquivel-Mora7, Icíar Pérez-Rodrigo8, José M Cisneros9, Walter-Alfredo Goycochea-Valdivia10, Olaf Neth11. 1. Department of Pharmacy, Institute of Biomedicine of Seville (IBIS), Hospital Universitario Virgen del Rocío, Sevilla, Spain. 2. Department of Pharmacy, Hospital Gregorio Marañón. Instituto de Investigación Sanitaria Gregorio Marañón. Research Network on Maternal and Child Health and Development II (Red SAMID II). Spanish Health Institute Carlos III, Madrid, Spain. 3. Department of Pharmacy, Hospital Universitario Vall d'Hebron, Universidad Autónoma de Barcelona, PROA-NEN project, Barcelona, Spain. 4. Paediatric Infectious Diseases and Immunodeficiencies Unit, Hospital Universitario Vall d'Hebron, Universidad Autónoma de Barcelona, PROA-NEN project, Barcelona, Spain. 5. Department of Pharmacy, Hospital Universitario Infanta Sofía, San Sebastián de los Reyes, Madrid, Spain. 6. Department of Pharmacy, Hospital Universitario de Jerez, Jeréz de la Frontera, Cádiz, Spain. 7. Department of Paediatrics, Hospital Universitario de Jerez, Jeréz de la Frontera, Cádiz, Spain. 8. Department of Pharmacy, Hospital Universitario Reina Sofía, Córdoba, Spain. 9. Department of Infectious Diseases, Microbiology and Preventive Medicine, Institute of Biomedicine of Seville (IBIS), University of Seville/CSIC/University Hospital Virgen del Rocío, Sevilla, Spain. 10. Paediatric Infectious Diseases, Rheumatology and Immunology Unit, Hospital Universitario Virgen del Rocío, Sevilla, Institute of Biomedicine of Seville (IBIS), Spain. Electronic address: alfgova@gmail.com. 11. Paediatric Infectious Diseases, Rheumatology and Immunology Unit, Hospital Universitario Virgen del Rocío, Sevilla, Institute of Biomedicine of Seville (IBIS), Spain.
Abstract
INTRODUCTION: Antimicrobial defined daily dose (DDD), has limitations for antimicrobial consumption measurement in paediatrics. An alternative DDD design applicable for children is proposed. METHODS: Children (<16 years-old) from 10 Spanish hospitals during a 12-months period were included. Weight for age (50th percentile) was calculated for the median age of the cohort using standardized World Health Organization tables. DDD (g) for each antimicrobial was calculated by multiplying the obtained weight times the recommended dose (mg/kg) of the antimicrobial for the most common infectious indication. RESULTS: A total of 40,575 children were included. Median age was 4.17 (IQR: 1.36-8.98) and 4.81 (IQR: 1.42-9.60) years for boys and girls, respectively. Mean weight for this age was 17.08kg. Standardized DDD for representative antimicrobials were calculated. CONCLUSIONS: A useful method for antimicrobial DDD measurement in paediatrics has been proposed and should be validated in future studies for its use in paediatric antimicrobial stewardship programmes.
INTRODUCTION: Antimicrobial defined daily dose (DDD), has limitations for antimicrobial consumption measurement in paediatrics. An alternative DDD design applicable for children is proposed. METHODS:Children (<16 years-old) from 10 Spanish hospitals during a 12-months period were included. Weight for age (50th percentile) was calculated for the median age of the cohort using standardized World Health Organization tables. DDD (g) for each antimicrobial was calculated by multiplying the obtained weight times the recommended dose (mg/kg) of the antimicrobial for the most common infectious indication. RESULTS: A total of 40,575 children were included. Median age was 4.17 (IQR: 1.36-8.98) and 4.81 (IQR: 1.42-9.60) years for boys and girls, respectively. Mean weight for this age was 17.08kg. Standardized DDD for representative antimicrobials were calculated. CONCLUSIONS: A useful method for antimicrobial DDD measurement in paediatrics has been proposed and should be validated in future studies for its use in paediatric antimicrobial stewardship programmes.
Authors: L Calle-Miguel; G Modroño Riaño; A I Iglesias Carbajo; M A Alonso Álvarez; C Vicente Martínez; G Solís Sánchez Journal: Rev Esp Quimioter Date: 2021-01-26 Impact factor: 1.553