Shahin Gaini1, Mette Marie Relster2, Court Pedersen2, Isik Somuncu Johansen2. 1. Department of Infectious Diseases, Odense University Hospital and University of Southern Denmark, Odense, Denmark; Infectious Diseases Division, Medical Department, National Hospital Faroe Islands, Tórshavn, Faroe Islands; Centre of Health Research and Department of Science and Technology, University of the Faroe Islands, Tórshavn, Faroe Islands. Electronic address: Lsshaga@Ls.fo. 2. Department of Infectious Diseases, Odense University Hospital and University of Southern Denmark, Odense, Denmark.
Abstract
AIMS: Evaluating the use of sequential organ failure assessment (SOFA) ≥ 2 compared to quick SOFA (qSOFA) and to systemic inflammatory response syndrome (SIRS) in assessing 28-days mortality in medical patients with acute infection. METHODS: In total, 323 patients with verified infection were stratified in accordance to Sepsis-3. SOFA, qSOFA and SIRS were calculated using registered variables. Adverse outcome was death within 28-days of admission. RESULTS: In total, 190 (59%) patients had a SOFA score≥2 and the overall in-hospital mortality was 21 (6%). Scores of SOFA and qSOFA were both significantly elevated in non-survivors. SOFA showed good accuracy (Area under the receiver operating characteristic (AUROC)=0.83, 95% CI, 0.76 - 0.90) for 28-days mortality compared with qSOFA (AUROC=0.67, 95% CI, 0.54 - 0.80) and SIRS (AUROC=0.62, 95% Cl 0.49 - 0.74). SOFA was≥2 in all patients who died, while qSOFA and SIRS was≥2 in 8 (38%) and 17 (81%) of the patients who died, respectively. CONCLUSION: SOFA score≥2 was better than SIRS and qSOFA to predict mortality within 28-days of admission among patients with acute infectious disease.
AIMS: Evaluating the use of sequential organ failure assessment (SOFA) ≥ 2 compared to quick SOFA (qSOFA) and to systemic inflammatory response syndrome (SIRS) in assessing 28-days mortality in medical patients with acute infection. METHODS: In total, 323 patients with verified infection were stratified in accordance to Sepsis-3. SOFA, qSOFA and SIRS were calculated using registered variables. Adverse outcome was death within 28-days of admission. RESULTS: In total, 190 (59%) patients had a SOFA score≥2 and the overall in-hospital mortality was 21 (6%). Scores of SOFA and qSOFA were both significantly elevated in non-survivors. SOFA showed good accuracy (Area under the receiver operating characteristic (AUROC)=0.83, 95% CI, 0.76 - 0.90) for 28-days mortality compared with qSOFA (AUROC=0.67, 95% CI, 0.54 - 0.80) and SIRS (AUROC=0.62, 95% Cl 0.49 - 0.74). SOFA was≥2 in all patients who died, while qSOFA and SIRS was≥2 in 8 (38%) and 17 (81%) of the patients who died, respectively. CONCLUSION: SOFA score≥2 was better than SIRS and qSOFA to predict mortality within 28-days of admission among patients with acute infectious disease.
Authors: Peter Bank Pedersen; Daniel Pilsgaard Henriksen; Mikkel Brabrand; Annmarie Touborg Lassen Journal: BMJ Open Date: 2019-10-30 Impact factor: 2.692
Authors: Raúl López-Izquierdo; Pablo Del Brio-Ibañez; Francisco Martín-Rodríguez; Alicia Mohedano-Moriano; Begoña Polonio-López; Clara Maestre-Miquel; Antonio Viñuela; Carlos Durantez-Fernández; Miguel Á Castro Villamor; José L Martín-Conty Journal: Int J Environ Res Public Health Date: 2020-11-12 Impact factor: 3.390