Literature DB >> 30267606

A guide to microRNA-mediated gene silencing.

Miguel Quévillon Huberdeau1,2, Martin J Simard1,2.   

Abstract

As an important regulator of gene expression in eukaryotes, microRNAs (miRNAs) have been subject to extensive research to understand their pleiotropic roles in development and pathological processes. Here, we review strategies that have been developed to map microRNA-target interactions and the most effective methods to attribute post-transcriptional gene regulation through miRNA-mediated silencing. We further discuss the importance of the biological context for silencing.
© 2018 Federation of European Biochemical Societies.

Keywords:  gene regulation; miRISC; microRNA target; microRNA target validation

Mesh：

Substances：

Year:  2018        PMID： 30267606     DOI： 10.1111/febs.14666

Source DB:  PubMed          Journal:  FEBS J        ISSN： 1742-464X            Impact factor:   5.542


  13 in total

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5.  In vivo CRISPR screening for phenotypic targets of the mir-35-42 family in C. elegans.

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8.  Does miR-618 rs2682818 variant affect cancer susceptibility? Evidence from 10 case-control studies.

Authors:  Xingliang Feng; Dan Ji; Chaozhao Liang; Song Fan
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10.  Placental microRNA expression associates with birthweight through control of adipokines: results from two independent cohorts.

Authors:  Elizabeth M Kennedy; Karen Hermetz; Amber Burt; Todd M Everson; Maya Deyssenroth; Ke Hao; Jia Chen; Margaret R Karagas; Dong Pei; Devin C Koestler; Carmen J Marsit
Journal:  Epigenetics       Date:  2020-10-04       Impact factor: 4.528
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