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Literature DB >> 30267337

Epigenetic influences on genetically triggered thoracic aortic aneurysm.

Stefanie S Portelli¹, Elizabeth N Robertson^2,3, Cassandra Malecki², Kiersten A Liddy², Brett D Hambly², Richmond W Jeremy^2,3.

Abstract

Genetically triggered thoracic aortic aneurysms (TAAs) account for 30% of all TAAs and can result in early morbidity and mortality in affected individuals. Epigenetic factors are now recognised to influence the phenotype of many genetically triggered conditions and have become an area of interest because of the potential for therapeutic manipulation. Major epigenetic modulators include DNA methylation, histone modification and non-coding RNA. This review examines epigenetic modulators that have been significantly associated with genetically triggered TAAs and their potential utility for translation to clinical practice.

Entities: Disease

Keywords: Aortic dilatation; Epigenetics; MicroRNA; Non-coding RNA; Thoracic aortic aneurysm

Year: 2018 PMID： 30267337 PMCID： PMC6233334 DOI： 10.1007/s12551-018-0460-1

Source DB: PubMed Journal: Biophys Rev ISSN： 1867-2450

145 in total

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Authors: Anton Wutz; Theodore P Rasmussen; Rudolf Jaenisch
Journal: Nat Genet Date: 2002-01-07 Impact factor: 38.330

Review 2. Phenotypic plasticity and the epigenetics of human disease.

Authors: Andrew P Feinberg
Journal: Nature Date: 2007-05-24 Impact factor: 49.962

3. Potential role of miR-29b in modulation of Dnmt3a and Dnmt3b expression in primordial germ cells of female mouse embryos.

Authors: Shuji Takada; Eugene Berezikov; Young Lim Choi; Yoshihiro Yamashita; Hiroyuki Mano
Journal: RNA Date: 2009-06-09 Impact factor: 4.942

4. A microRNA profile comparison between thoracic aortic dissection and normal thoracic aorta indicates the potential role of microRNAs in contributing to thoracic aortic dissection pathogenesis.

Authors: Mingfang Liao; Sili Zou; Jianfeng Weng; Lewei Hou; Lin Yang; Zhiqing Zhao; Junmin Bao; Zaiping Jing
Journal: J Vasc Surg Date: 2011-02-18 Impact factor: 4.268

Epigenetic influences on genetically triggered thoracic aortic aneurysm.

1. Chromosomal silencing and localization are mediated by different domains of Xist RNA.

Review 2. Phenotypic plasticity and the epigenetics of human disease.

3. Potential role of miR-29b in modulation of Dnmt3a and Dnmt3b expression in primordial germ cells of female mouse embryos.

4. A microRNA profile comparison between thoracic aortic dissection and normal thoracic aorta indicates the potential role of microRNAs in contributing to thoracic aortic dissection pathogenesis.

5. Crystal structure of the nucleosome core particle at 2.8 A resolution.

6. Increased canonical WNT/β-catenin signalling and myxomatous valve disease.

Review 7. LncRNAs in vascular biology and disease.

Review 8. Role of mechanotransduction in vascular biology: focus on thoracic aortic aneurysms and dissections.

9. Cytosine methylation and CpG, TpG (CpA) and TpA frequencies.

10. MicroRNA-17-92, a direct Ap-2α transcriptional target, modulates T-box factor activity in orofacial clefting.

Review 1. The RNA-binding fragile-X mental retardation protein and its role beyond the brain.

Review 2. Rare Causes of Arterial Hypertension and Thoracic Aortic Aneurysms-A Case-Based Review.