Shiue-Cheng Tang1, Claire F Jessup2, Martha Campbell-Thompson3. 1. Department of Medical Science and Institute of Biotechnology, National Tsing Hua University, Hsinchu, 30013, Taiwan. sctang@life.nthu.edu.tw. 2. College of Medicine and Public Health, Flinders University and Discipline of Medicine, University of Adelaide, Adelaide, SA, 5001, Australia. claire.jessup@flinders.edu.au. 3. Department of Pathology, Immunology, and Laboratory Medicine, 1395 Center Drive, College of Medicine, University of Florida, Gainesville, FL, 32610, USA. thompmc@pathology.ufl.edu.
Abstract
PURPOSES OF REVIEW: Scattered throughout the pancreas, the endocrine islets rely on neurovascular support for signal relay to regulate hormone secretion and for maintaining tissue homeostasis. The islet accessory cells (or components) of neurovascular tissues include the endothelial cells, pericytes, smooth muscle cells, neurons (nerve fibers), and glia. Research results derived from experimental diabetes and islet transplantation indicate that the accessory cells are reactive in islet injury and can affect islet function and homeostasis in situ or in an ectopic environment. RECENT FINDINGS: Recent advances in cell labeling and tissue imaging have enabled investigation of islet accessory cells to gain insights into their network structures, functions, and remodeling in disease. It has become clear that in diabetes, the islet neurovascular tissues are not just bystanders damaged in neuropathy and vascular complications; rather, they participate in islet remodeling in response to changes in the microenvironment. Because of the fundamental differences between humans and animal models in neuroinsular cytoarchitecture and cell proliferation, examination of islet accessory cells in clinical specimens and donor pancreases warrants further attention.
PURPOSES OF REVIEW: Scattered throughout the pancreas, the endocrine islets rely on neurovascular support for signal relay to regulate hormone secretion and for maintaining tissue homeostasis. The islet accessory cells (or components) of neurovascular tissues include the endothelial cells, pericytes, smooth muscle cells, neurons (nerve fibers), and glia. Research results derived from experimental diabetes and islet transplantation indicate that the accessory cells are reactive in islet injury and can affect islet function and homeostasis in situ or in an ectopic environment. RECENT FINDINGS: Recent advances in cell labeling and tissue imaging have enabled investigation of islet accessory cells to gain insights into their network structures, functions, and remodeling in disease. It has become clear that in diabetes, the islet neurovascular tissues are not just bystanders damaged in neuropathy and vascular complications; rather, they participate in islet remodeling in response to changes in the microenvironment. Because of the fundamental differences between humans and animal models in neuroinsular cytoarchitecture and cell proliferation, examination of islet accessory cells in clinical specimens and donor pancreases warrants further attention.
Authors: M'Balu A Webb; Severine C Illouz; Cristina A Pollard; Robert Gregory; John F Mayberry; Simon G Tordoff; Margaret Bone; Christine J Cordle; David P Berry; Michael L Nicholson; Patrick P Musto; Ashley R Dennison Journal: Pancreas Date: 2008-10 Impact factor: 3.327
Authors: M Nakamura; H Kitamura; S Konishi; M Nishimura; J Ono; K Ina; T Shimada; R Takaki Journal: Diabetes Res Clin Pract Date: 1995-11 Impact factor: 5.602
Authors: Leif Jansson; Andreea Barbu; Birgitta Bodin; Carl Johan Drott; Daniel Espes; Xiang Gao; Liza Grapensparr; Örjan Källskog; Joey Lau; Hanna Liljebäck; Fredrik Palm; My Quach; Monica Sandberg; Victoria Strömberg; Sara Ullsten; Per-Ola Carlsson Journal: Ups J Med Sci Date: 2016-04-28 Impact factor: 2.384
Authors: Elliott W Dirr; Morgan E Urdaneta; Yogi Patel; Richard D Johnson; Martha Campbell-Thompson; Kevin J Otto Journal: Bioelectron Med (Lond) Date: 2020-07-28
Authors: Alexandra Alvarsson; Maria Jimenez-Gonzalez; Rosemary Li; Carolina Rosselot; Nikolaos Tzavaras; Zhuhao Wu; Andrew F Stewart; Adolfo Garcia-Ocaña; Sarah A Stanley Journal: Sci Adv Date: 2020-10-09 Impact factor: 14.136
Authors: Martha Campbell-Thompson; Elizabeth A Butterworth; J Lucas Boatwright; Malavika A Nair; Lith H Nasif; Kamal Nasif; Andy Y Revell; Alberto Riva; Clayton E Mathews; Ivan C Gerling; Desmond A Schatz; Mark A Atkinson Journal: Sci Rep Date: 2021-03-22 Impact factor: 4.379