Tiina-Riitta Vuorjoki-Ranta1, Ghizlane Aarab2, Frank Lobbezoo2, Henri Tuomilehto3,4, Jari Ahlberg5,6,7. 1. City of Helsinki, Department of Social Services and Health Care, POB 6420, 00099, Helsinki, Finland. tiina-riitta.vuorjoki-ranta@hel.fi. 2. Department of Oral Kinesiology, Academic Centre for Dentistry Amsterdam (ACTA), Research Institute MOVE, University of Amsterdam and VU University Amsterdam, Amsterdam, The Netherlands. 3. Oivauni Sleep Clinic, Kuopio, Finland. 4. Institute of Public Health and Clinical Nutrition, Department of Clinical Nutrition, University of Eastern Finland, Kuopio, Finland. 5. Oral and Maxillofacial Diseases, University of Helsinki, Helsinki, Finland. 6. City of Helsinki, Department of Social Services and Health Care, Unit for Specialized Oral Care in the Metropolitan Area and Kirkkonummi, Helsinki, Finland. 7. Institute of Dentistry, University of Eastern Finland, Kuopio, Finland.
Abstract
PURPOSE: The aim was to analyze whether or not weight gain influences the treatment outcome of patients with obstructive sleep apnea (OSA) treated with mandibular advancement devices (MAD). METHODS: As a part of a follow-up study among OSA patients treated with MAD in primary oral health care, a group of 28 patients reporting worsening of daytime or nighttime symptoms of OSA was given closer examination. Altogether, 21 subjects had a complete set of recordings and were enrolled into the study. RESULTS: Only three subjects had lost weight during the study period. The mean weight gain of 3.6 kg ± 7.1 kg was significant (p = 0.035). According to linear regression, weight gain was independently significantly associated with lower mean peripheral oxygen saturation 92.4 (SD 1.8 (% per hour) (p = 0.019)) and lowest oxygen saturation 80.1 (SD 7.2 (%) (p = 0.024)) scores. CONCLUSIONS: Weight gain is detrimentally associated with MAD treatment in patients with OSA. These findings suggest that regular follow-up by an experienced dentist is advisable to assess for possible worsening of OSA. Patient support to encourage weight control may be an important adjunct to MAD treatment for OSA.
PURPOSE: The aim was to analyze whether or not weight gain influences the treatment outcome of patients with obstructive sleep apnea (OSA) treated with mandibular advancement devices (MAD). METHODS: As a part of a follow-up study among OSA patients treated with MAD in primary oral health care, a group of 28 patients reporting worsening of daytime or nighttime symptoms of OSA was given closer examination. Altogether, 21 subjects had a complete set of recordings and were enrolled into the study. RESULTS: Only three subjects had lost weight during the study period. The mean weight gain of 3.6 kg ± 7.1 kg was significant (p = 0.035). According to linear regression, weight gain was independently significantly associated with lower mean peripheral oxygen saturation 92.4 (SD 1.8 (% per hour) (p = 0.019)) and lowest oxygen saturation 80.1 (SD 7.2 (%) (p = 0.024)) scores. CONCLUSIONS:Weight gain is detrimentally associated with MAD treatment in patients with OSA. These findings suggest that regular follow-up by an experienced dentist is advisable to assess for possible worsening of OSA. Patient support to encourage weight control may be an important adjunct to MAD treatment for OSA.
Entities:
Keywords:
Mandibular advancement device; Obstructive sleep apnea; Overweight; Primary health care
Authors: Lawrence J Epstein; David Kristo; Patrick J Strollo; Norman Friedman; Atul Malhotra; Susheel P Patil; Kannan Ramar; Robert Rogers; Richard J Schwab; Edward M Weaver; Michael D Weinstein Journal: J Clin Sleep Med Date: 2009-06-15 Impact factor: 4.062
Authors: Henri P I Tuomilehto; Juha M Seppä; Markku M Partinen; Markku Peltonen; Helena Gylling; Jaakko O I Tuomilehto; Esko J Vanninen; Jouko Kokkarinen; Johanna K Sahlman; Tarja Martikainen; Erkki J O Soini; Jukka Randell; Hannu Tukiainen; Matti Uusitupa Journal: Am J Respir Crit Care Med Date: 2008-11-14 Impact factor: 21.405