Literature DB >> 30263949

Local unwinding of double-strand DNA ends by the MRX complex promotes Exo1 processing activity.

Elisa Gobbini1, Jacopo Vertemara1, Maria Pia Longhese1.   

Abstract

Homologous recombination is initiated by nucleolytic degradation (resection) of DNA double-strand breaks (DSBs), which involves different nucleases including the Mre11-Rad50-Xrs2 (MRX) complex and the Exonuclease 1 (Exo1). The characterization of a novel mutation in Mre11 causing accelerated DSB resection has allowed to show that MRX facilitates DNA end processing by Exo1 through local unwinding of double-stranded DNA ends.

Entities:  

Keywords:  Exo1; MRX; S. cerevisiae; double-strand break; resection

Year:  2018        PMID： 30263949      PMCID： PMC6154851          DOI： 10.1080/23723556.2018.1511208

Source DB:  PubMed          Journal:  Mol Cell Oncol        ISSN： 2372-3556


  10 in total

1.  Nbs1 potentiates ATP-driven DNA unwinding and endonuclease cleavage by the Mre11/Rad50 complex.

Authors:  T T Paull; M Gellert
Journal:  Genes Dev       Date:  1999-05-15       Impact factor: 11.361

2.  ATP-dependent DNA binding, unwinding, and resection by the Mre11/Rad50 complex.

Authors:  Yaqi Liu; Sihyun Sung; Youngran Kim; Fuyang Li; Gwanghyun Gwon; Aera Jo; Ae-Kyoung Kim; Taeyoon Kim; Ok-Kyu Song; Sang Eun Lee; Yunje Cho
Journal:  EMBO J       Date:  2015-12-30       Impact factor: 11.598

3.  The MRX complex regulates Exo1 resection activity by altering DNA end structure.

Authors:  Elisa Gobbini; Corinne Cassani; Jacopo Vertemara; Weibin Wang; Fabiana Mambretti; Erika Casari; Patrick Sung; Renata Tisi; Giuseppe Zampella; Maria Pia Longhese
Journal:  EMBO J       Date:  2018-06-19       Impact factor: 11.598

4.  Relationship of DNA degradation by Saccharomyces cerevisiae exonuclease 1 and its stimulation by RPA and Mre11-Rad50-Xrs2 to DNA end resection.

Authors:  Elda Cannavo; Petr Cejka; Stephen C Kowalczykowski
Journal:  Proc Natl Acad Sci U S A       Date:  2013-04-15       Impact factor: 11.205

Review 5.  Mechanism and regulation of DNA end resection in eukaryotes.

Authors:  Lorraine S Symington
Journal:  Crit Rev Biochem Mol Biol       Date:  2016-04-20       Impact factor: 8.250

6.  Single-molecule imaging reveals the mechanism of Exo1 regulation by single-stranded DNA binding proteins.

Authors:  Logan R Myler; Ignacio F Gallardo; Yi Zhou; Fade Gong; Soo-Hyun Yang; Marc S Wold; Kyle M Miller; Tanya T Paull; Ilya J Finkelstein
Journal:  Proc Natl Acad Sci U S A       Date:  2016-02-16       Impact factor: 11.205

7.  Mre11-Rad50-Xrs2 and Sae2 promote 5' strand resection of DNA double-strand breaks.

Authors:  Matthew L Nicolette; Kihoon Lee; Zhi Guo; Mridula Rani; Julia M Chow; Sang Eun Lee; Tanya T Paull
Journal:  Nat Struct Mol Biol       Date:  2010-11-21       Impact factor: 15.369

8.  The RNA binding protein Npl3 promotes resection of DNA double-strand breaks by regulating the levels of Exo1.

Authors:  Chiara Vittoria Colombo; Camilla Trovesi; Luca Menin; Maria Pia Longhese; Michela Clerici
Journal:  Nucleic Acids Res       Date:  2017-06-20       Impact factor: 16.971

9.  Checkpoint-dependent phosphorylation of Exo1 modulates the DNA damage response.

Authors:  Isabelle Morin; Hien-Ping Ngo; Amanda Greenall; Mikhajlo K Zubko; Nick Morrice; David Lydall
Journal:  EMBO J       Date:  2008-08-28       Impact factor: 11.598

10.  Phosphorylation of EXO1 by CDKs 1 and 2 regulates DNA end resection and repair pathway choice.

Authors:  Nozomi Tomimatsu; Bipasha Mukherjee; Molly Catherine Hardebeck; Mariya Ilcheva; Cristel Vanessa Camacho; Janelle Louise Harris; Matthew Porteus; Bertrand Llorente; Kum Kum Khanna; Sandeep Burma
Journal:  Nat Commun       Date:  2014-04-07       Impact factor: 14.919
  10 in total
  2 in total

Review 1.  Functional and structural insights into the MRX/MRN complex, a key player in recognition and repair of DNA double-strand breaks.

Authors:  Renata Tisi; Jacopo Vertemara; Giuseppe Zampella; Maria Pia Longhese
Journal:  Comput Struct Biotechnol J       Date:  2020-05-16       Impact factor: 7.271

2.  Mapping yeast mitotic 5' resection at base resolution reveals the sequence and positional dependence of nucleases in vivo.

Authors:  Dominic Bazzano; Stephanie Lomonaco; Thomas E Wilson
Journal:  Nucleic Acids Res       Date:  2021-12-16       Impact factor: 16.971
  2 in total

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