Literature DB >> 30263941

Dual mechanism of DICER downregulation facilitates cancer metastasis.

Hui-Huang Lai1,2, Pai-Sheng Chen1,2.   

Abstract

Although downregulation of DICER - a critical enzyme in microRNA (miRNA) maturation - reportedly promotes cancer metastasis, understanding of its upstream regulators remains limited. Our recent study demonstrated a noncanonical oncogenic effect of hypoxia-inducible factor-1α (HIF-1α), which directly binds with DICER to promote PARKIN-mediated autophagic-lysosomal proteolysis and consequently suppresses miRNA biogenesis, facilitating metastasis.

Entities:  

Keywords:  DICER; HIF-1α; metastasis; miRNA

Year:  2018        PMID： 30263941      PMCID： PMC6154833          DOI： 10.1080/23723556.2018.1472056

Source DB:  PubMed          Journal:  Mol Cell Oncol        ISSN： 2372-3556


  10 in total

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Journal:  Nat Rev Cancer       Date:  2015-06       Impact factor: 60.716

2.  Functional importance of Dicer protein in the adaptive cellular response to hypoxia.

Authors:  J J David Ho; Julie L Metcalf; Matthew S Yan; Paul J Turgeon; Jenny Jing Wang; Maria Chalsev; Tania N Petruzziello-Pellegrini; Albert K Y Tsui; Jeff Z He; Helena Dhamko; H S Jeffrey Man; G Brett Robb; Bin T Teh; Michael Ohh; Philip A Marsden
Journal:  J Biol Chem       Date:  2012-06-28       Impact factor: 5.157

3.  HIF-1α promotes autophagic proteolysis of Dicer and enhances tumor metastasis.

Authors:  Hui-Huang Lai; Jie-Ning Li; Ming-Yang Wang; Hsin-Yi Huang; Carlo M Croce; Hui-Lung Sun; Yu-Jhen Lyu; Jui-Wen Kang; Ching-Feng Chiu; Mien-Chie Hung; Hiroshi I Suzuki; Pai-Sheng Chen
Journal:  J Clin Invest       Date:  2017-12-18       Impact factor: 14.808

4.  Impaired microRNA processing enhances cellular transformation and tumorigenesis.

Authors:  Madhu S Kumar; Jun Lu; Kim L Mercer; Todd R Golub; Tyler Jacks
Journal:  Nat Genet       Date:  2007-04-01       Impact factor: 38.330

5.  A MicroRNA targeting dicer for metastasis control.

Authors:  Graziano Martello; Antonio Rosato; Francesco Ferrari; Andrea Manfrin; Michelangelo Cordenonsi; Sirio Dupont; Elena Enzo; Vincenza Guzzardo; Maria Rondina; Thomas Spruce; Anna R Parenti; Maria Grazia Daidone; Silvio Bicciato; Stefano Piccolo
Journal:  Cell       Date:  2010-06-25       Impact factor: 41.582

6.  Dicer1 functions as a haploinsufficient tumor suppressor.

Authors:  Madhu S Kumar; Ryan E Pester; Cindy Y Chen; Keara Lane; Christine Chin; Jun Lu; David G Kirsch; Todd R Golub; Tyler Jacks
Journal:  Genes Dev       Date:  2009-11-10       Impact factor: 11.361

Review 7.  Targeting HIF-1 for cancer therapy.

Authors:  Gregg L Semenza
Journal:  Nat Rev Cancer       Date:  2003-10       Impact factor: 60.716

8.  Hypoxia promotes stem cell phenotypes and poor prognosis through epigenetic regulation of DICER.

Authors:  Twan van den Beucken; Elizabeth Koch; Kenneth Chu; Rajesha Rupaimoole; Peggy Prickaerts; Michiel Adriaens; Jan Willem Voncken; Adrian L Harris; Francesca M Buffa; Syed Haider; Maud H W Starmans; Cindy Q Yao; Mircea Ivan; Cristina Ivan; Chad V Pecot; Paul C Boutros; Anil K Sood; Marianne Koritzinsky; Bradly G Wouters
Journal:  Nat Commun       Date:  2014-10-29       Impact factor: 14.919

9.  Hypoxia-mediated downregulation of miRNA biogenesis promotes tumour progression.

Authors:  Rajesha Rupaimoole; Sherry Y Wu; Sunila Pradeep; Cristina Ivan; Chad V Pecot; Kshipra M Gharpure; Archana S Nagaraja; Guillermo N Armaiz-Pena; Michael McGuire; Behrouz Zand; Heather J Dalton; Justyna Filant; Justin Bottsford Miller; Chunhua Lu; Nouara C Sadaoui; Lingegowda S Mangala; Morgan Taylor; Twan van den Beucken; Elizabeth Koch; Cristian Rodriguez-Aguayo; Li Huang; Menashe Bar-Eli; Bradly G Wouters; Milan Radovich; Mircea Ivan; George A Calin; Wei Zhang; Gabriel Lopez-Berestein; Anil K Sood
Journal:  Nat Commun       Date:  2014-10-29       Impact factor: 14.919

10.  Parkin targets HIF-1α for ubiquitination and degradation to inhibit breast tumor progression.

Authors:  Juan Liu; Cen Zhang; Yuhan Zhao; Xuetian Yue; Hao Wu; Shan Huang; James Chen; Kyle Tomsky; Haiyang Xie; Christen A Khella; Michael L Gatza; Dajing Xia; Jimin Gao; Eileen White; Bruce G Haffty; Wenwei Hu; Zhaohui Feng
Journal:  Nat Commun       Date:  2017-11-28       Impact factor: 14.919
  10 in total
  1 in total

Review 1.  The role of miR-200 family in the regulation of hallmarks of cancer.

Authors:  Klaudia Klicka; Tomasz M Grzywa; Aleksandra Mielniczuk; Alicja Klinke; Paweł K Włodarski
Journal:  Front Oncol       Date:  2022-09-08       Impact factor: 5.738
  1 in total

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