Literature DB >> 30263934

Protein kinase Cι: A versatile oncogene in the lung.

Alan P Fields1, Syed A Ali1, Verline Justilien1, Nicole R Murray1.   

Abstract

We have recently demonstrated that protein kinase Cι (PKCι) promotes a stem-like, tumor-initiating cell phenotype in KRAS-driven lung adenocarcinoma by activating a novel ELF3-NOTCH3 signaling axis.1 Combined PKCι and NOTCH inhibition was identified as a novel strategy for the treatment of KRAS-driven lung adenocarcinoma.

Entities:  

Keywords:  Gene amplification; Protein Kinase Ciota; lung adenocarcinoma; lung squamous cell carcinoma; non-small cell lung cancer; therapeutic targeting

Year:  2018        PMID： 30263934      PMCID： PMC6154840          DOI： 10.1080/23723556.2016.1190886

Source DB:  PubMed          Journal:  Mol Cell Oncol        ISSN： 2372-3556


  10 in total

1.  Oncogenic activity of Ect2 is regulated through protein kinase C iota-mediated phosphorylation.

Authors:  Verline Justilien; Lee Jameison; Channing J Der; Kent L Rossman; Alan P Fields
Journal:  J Biol Chem       Date:  2010-12-28       Impact factor: 5.157

Review 2.  Atypical protein kinase Cι as a human oncogene and therapeutic target.

Authors:  Peter J Parker; Verline Justilien; Philippe Riou; Mark Linch; Alan P Fields
Journal:  Biochem Pharmacol       Date:  2013-11-11       Impact factor: 5.858

3.  Atypical protein kinase C iota is an oncogene in human non-small cell lung cancer.

Authors:  Roderick P Regala; Capella Weems; Lee Jamieson; Andras Khoor; Eric S Edell; Christine M Lohse; Alan P Fields
Journal:  Cancer Res       Date:  2005-10-01       Impact factor: 12.701

4.  A mixed-methods feasibility trial of protein kinase C iota inhibition with auranofin in asymptomatic ovarian cancer patients.

Authors:  Aminah Jatoi; Carmen Radecki Breitkopf; Nathan R Foster; Matthew S Block; Megan Grudem; Andrea Wahner Hendrickson; Rachel E Carlson; Brigitte Barrette; Nina Karlin; Alan P Fields
Journal:  Oncology       Date:  2014-12-06       Impact factor: 2.935

5.  The PRKCI and SOX2 oncogenes are coamplified and cooperate to activate Hedgehog signaling in lung squamous cell carcinoma.

Authors:  Verline Justilien; Michael P Walsh; Syed A Ali; E Aubrey Thompson; Nicole R Murray; Alan P Fields
Journal:  Cancer Cell       Date:  2014-02-10       Impact factor: 31.743

Review 6.  Molecular pathways: novel approaches for improved therapeutic targeting of Hedgehog signaling in cancer stem cells.

Authors:  Verline Justilien; Alan P Fields
Journal:  Clin Cancer Res       Date:  2015-02-01       Impact factor: 12.531

7.  Protein Kinase Cι Drives a NOTCH3-dependent Stem-like Phenotype in Mutant KRAS Lung Adenocarcinoma.

Authors:  Syed A Ali; Verline Justilien; Lee Jamieson; Nicole R Murray; Alan P Fields
Journal:  Cancer Cell       Date:  2016-03-14       Impact factor: 31.743

8.  Phase I dose escalation study of the PKCι inhibitor aurothiomalate for advanced non-small-cell lung cancer, ovarian cancer, and pancreatic cancer.

Authors:  Aaron S Mansfield; Alan P Fields; Aminah Jatoi; Yingwei Qi; Alex A Adjei; Charles Erlichman; Julian R Molina
Journal:  Anticancer Drugs       Date:  2013-11       Impact factor: 2.248

9.  Atypical protein kinase C{iota} is required for bronchioalveolar stem cell expansion and lung tumorigenesis.

Authors:  Roderick P Regala; Rebecca K Davis; Alyssa Kunz; Andras Khoor; Michael Leitges; Alan P Fields
Journal:  Cancer Res       Date:  2009-09-08       Impact factor: 12.701

10.  Ect2 links the PKCiota-Par6alpha complex to Rac1 activation and cellular transformation.

Authors:  V Justilien; A P Fields
Journal:  Oncogene       Date:  2009-07-20       Impact factor: 9.867
  10 in total
  1 in total

1.  FoxM1 insufficiency hyperactivates Ect2-RhoA-mDia1 signaling to drive cancer.

Authors:  Jazeel F Limzerwala; Karthik B Jeganathan; Jake A Kloeber; Brian A Davies; Cheng Zhang; Ines Sturmlechner; Jian Zhong; Raul Fierro Velasco; Alan P Fields; Yaxia Yuan; Darren J Baker; Daohong Zhou; Hu Li; David J Katzmann; Jan M van Deursen
Journal:  Nat Cancer       Date:  2020-10-12
  1 in total

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