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Literature DB >> 30263932

Mitochondrial and Lipid Droplet Dynamics Regulate Intra- and Intercellular Fatty Acid Trafficking.

Sarah Cohen^1,2, Angelika S Rambold^3,2, Jennifer Lippincott-Schwartz¹.

Abstract

Imaging of fatty acid (FA) trafficking revealed that FAs stored in lipid droplets were delivered to mitochondria when the cells were starved. This delivery required cytoplasmic lipases and mitochondrial fusion activity, whereas lipid droplets were replenished with FAs supplied by autophagy. These findings have important implications for cancer.

Entities: Chemical Disease

Keywords: Mfn1; Opa1; autophagy; fatty acid; lipase; lipid droplet; lipophagy; mitochondria; tumor metabolism; tumor-stroma interactions

Year: 2018 PMID： 30263932 PMCID： PMC6154839 DOI： 10.1080/23723556.2015.1043038

Source DB: PubMed Journal: Mol Cell Oncol ISSN： 2372-3556

10 in total

1. Fatty acid trafficking in starved cells: regulation by lipid droplet lipolysis, autophagy, and mitochondrial fusion dynamics.

Authors: Angelika S Rambold; Sarah Cohen; Jennifer Lippincott-Schwartz
Journal: Dev Cell Date: 2015-03-05 Impact factor: 12.270

2. Adipocytes promote ovarian cancer metastasis and provide energy for rapid tumor growth.

Authors: Kristin M Nieman; Hilary A Kenny; Carla V Penicka; Andras Ladanyi; Rebecca Buell-Gutbrod; Marion R Zillhardt; Iris L Romero; Mark S Carey; Gordon B Mills; Gökhan S Hotamisligil; S Diane Yamada; Marcus E Peter; Katja Gwin; Ernst Lengyel
Journal: Nat Med Date: 2011-10-30 Impact factor: 53.440

3. Tubular network formation protects mitochondria from autophagosomal degradation during nutrient starvation.

Authors: Angelika S Rambold; Brenda Kostelecky; Natalie Elia; Jennifer Lippincott-Schwartz
Journal: Proc Natl Acad Sci U S A Date: 2011-06-06 Impact factor: 11.205

4. Power surge: supporting cells "fuel" cancer cell mitochondria.

Authors: Ubaldo E Martinez-Outschoorn; Federica Sotgia; Michael P Lisanti
Journal: Cell Metab Date: 2012-01-04 Impact factor: 27.287

Review 5. Lipid homeostasis, lipotoxicity and the metabolic syndrome.

Authors: Roger H Unger; Gregory O Clark; Philipp E Scherer; Lelio Orci
Journal: Biochim Biophys Acta Date: 2009-11-27

6. Autophagy regulates lipid metabolism.

Authors: Rajat Singh; Susmita Kaushik; Yongjun Wang; Youqing Xiang; Inna Novak; Masaaki Komatsu; Keiji Tanaka; Ana Maria Cuervo; Mark J Czaja
Journal: Nature Date: 2009-04-01 Impact factor: 49.962

Review 7. FAT SIGNALS--lipases and lipolysis in lipid metabolism and signaling.

Authors: Rudolf Zechner; Robert Zimmermann; Thomas O Eichmann; Sepp D Kohlwein; Guenter Haemmerle; Achim Lass; Frank Madeo
Journal: Cell Metab Date: 2012-03-07 Impact factor: 27.287

8. Mitochondrial fission induces glycolytic reprogramming in cancer-associated myofibroblasts, driving stromal lactate production, and early tumor growth.

Authors: Carmela Guido; Diana Whitaker-Menezes; Zhao Lin; Richard G Pestell; Anthony Howell; Teresa A Zimmers; Mathew C Casimiro; Saveria Aquila; Sebastiano Ando'; Ubaldo E Martinez-Outschoorn; Federica Sotgia; Michael P Lisanti
Journal: Oncotarget Date: 2012-08

9. Two-compartment tumor metabolism: autophagy in the tumor microenvironment and oxidative mitochondrial metabolism (OXPHOS) in cancer cells.

Authors: Ahmed F Salem; Diana Whitaker-Menezes; Zhao Lin; Ubaldo E Martinez-Outschoorn; Herbert B Tanowitz; Mazhar Salim Al-Zoubi; Anthony Howell; Richard G Pestell; Federica Sotgia; Michael P Lisanti
Journal: Cell Cycle Date: 2012-07-01 Impact factor: 4.534

10. Mitochondrial dynamics regulates migration and invasion of breast cancer cells.

Authors: J Zhao; J Zhang; M Yu; Y Xie; Y Huang; D W Wolff; P W Abel; Y Tu
Journal: Oncogene Date: 2012-11-05 Impact factor: 9.867