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Literature DB >> 30263930

Mitochondrial Genome Transfer to Tumor Cells Breaks The Rules and Establishes a New Precedent in Cancer Biology.

Michael V Berridge¹, Carole Crasso¹, Jiri Neuzil^2,3.

Abstract

Horizontal gene transfer is known to occur in bacteria and archaea whereas higher organisms including mammals undergo vertical transfer. Our recent results demonstrate horizontal transfer of mitochondrial DNA (mtDNA) from normal host cells to tumor cells lacking mitochondrial DNA (mtDNA). This mtDNA migration results in recovery of respiration, restored tumor initiation, and metastasis.

Entities: Disease

Keywords: intercellular DNA transfer; metastasis; mitochondrial DNA deletion; respiration; tumor growth

Year: 2018 PMID： 30263930 PMCID： PMC6154849 DOI： 10.1080/23723556.2015.1023929

Source DB: PubMed Journal: Mol Cell Oncol ISSN： 2372-3556

10 in total

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Authors: Amin Rustom; Rainer Saffrich; Ivanka Markovic; Paul Walther; Hans-Hermann Gerdes
Journal: Science Date: 2004-02-13 Impact factor: 47.728

2. Mitochondrial transfer from bone-marrow-derived stromal cells to pulmonary alveoli protects against acute lung injury.

Authors: Mohammad Naimul Islam; Shonit R Das; Memet T Emin; Michelle Wei; Li Sun; Kristin Westphalen; David J Rowlands; Sadiqa K Quadri; Sunita Bhattacharya; Jahar Bhattacharya
Journal: Nat Med Date: 2012-04-15 Impact factor: 53.440

3. Mitochondrial transfer between cells can rescue aerobic respiration.

Authors: Jeffrey L Spees; Scott D Olson; Mandolin J Whitney; Darwin J Prockop
Journal: Proc Natl Acad Sci U S A Date: 2006-01-23 Impact factor: 11.205

Review 4. When cells become organelle donors.

Authors: Robert S Rogers; Jahar Bhattacharya
Journal: Physiology (Bethesda) Date: 2013-11

5. Mitochondrial genome acquisition restores respiratory function and tumorigenic potential of cancer cells without mitochondrial DNA.

Authors: An S Tan; James W Baty; Lan-Feng Dong; Ayenachew Bezawork-Geleta; Berwini Endaya; Jacob Goodwin; Martina Bajzikova; Jaromira Kovarova; Martin Peterka; Bing Yan; Elham Alizadeh Pesdar; Margarita Sobol; Anatolyj Filimonenko; Shani Stuart; Magdalena Vondrusova; Katarina Kluckova; Karishma Sachaphibulkij; Jakub Rohlena; Pavel Hozak; Jaroslav Truksa; David Eccles; Larisa M Haupt; Lyn R Griffiths; Jiri Neuzil; Michael V Berridge
Journal: Cell Metab Date: 2015-01-06 Impact factor: 27.287

6. Transcellular degradation of axonal mitochondria.

Authors: Chung-ha O Davis; Keun-Young Kim; Eric A Bushong; Elizabeth A Mills; Daniela Boassa; Tiffany Shih; Mira Kinebuchi; Sebastien Phan; Yi Zhou; Nathan A Bihlmeyer; Judy V Nguyen; Yunju Jin; Mark H Ellisman; Nicholas Marsh-Armstrong
Journal: Proc Natl Acad Sci U S A Date: 2014-06-16 Impact factor: 11.205

Review 7. Mitochondria and cancer.

Authors: Douglas C Wallace
Journal: Nat Rev Cancer Date: 2012-10 Impact factor: 60.716

Review 8. Hallmarks of cancer: the next generation.

Authors: Douglas Hanahan; Robert A Weinberg
Journal: Cell Date: 2011-03-04 Impact factor: 41.582

9. Transfer of mitochondria via tunneling nanotubes rescues apoptotic PC12 cells.

Authors: X Wang; H-H Gerdes
Journal: Cell Death Differ Date: 2015-01-09 Impact factor: 15.828

10. PGC-1α mediates mitochondrial biogenesis and oxidative phosphorylation in cancer cells to promote metastasis.

Authors: Valerie S LeBleu; Joyce T O'Connell; Karina N Gonzalez Herrera; Harriet Wikman; Klaus Pantel; Marcia C Haigis; Fernanda Machado de Carvalho; Aline Damascena; Ludmilla Thome Domingos Chinen; Rafael M Rocha; John M Asara; Raghu Kalluri
Journal: Nat Cell Biol Date: 2014-09-21 Impact factor: 28.824

10 in total

8 in total

Review 1. Roles of the mitochondrial genetics in cancer metastasis: not to be ignored any longer.

Authors: Thomas C Beadnell; Adam D Scheid; Carolyn J Vivian; Danny R Welch
Journal: Cancer Metastasis Rev Date: 2018-12 Impact factor: 9.264

2. Metabolic reprogramming of normal oral fibroblasts correlated with increased glycolytic metabolism of oral squamous cell carcinoma and precedes their activation into carcinoma associated fibroblasts.

Authors: Zhuoyuan Zhang; Zhenjie Gao; Saroj Rajthala; Dipak Sapkota; Harsh Dongre; Himalaya Parajuli; Salwa Suliman; Ridhima Das; Longjiang Li; Laurence A Bindoff; Daniela Elena Costea; Xiao Liang
Journal: Cell Mol Life Sci Date: 2019-07-03 Impact factor: 9.261

Mitochondrial Genome Transfer to Tumor Cells Breaks The Rules and Establishes a New Precedent in Cancer Biology.

1. Nanotubular highways for intercellular organelle transport.

2. Mitochondrial transfer from bone-marrow-derived stromal cells to pulmonary alveoli protects against acute lung injury.

3. Mitochondrial transfer between cells can rescue aerobic respiration.

Review 4. When cells become organelle donors.

5. Mitochondrial genome acquisition restores respiratory function and tumorigenic potential of cancer cells without mitochondrial DNA.

6. Transcellular degradation of axonal mitochondria.

Review 7. Mitochondria and cancer.

Review 8. Hallmarks of cancer: the next generation.

9. Transfer of mitochondria via tunneling nanotubes rescues apoptotic PC12 cells.

10. PGC-1α mediates mitochondrial biogenesis and oxidative phosphorylation in cancer cells to promote metastasis.

Review 1. Roles of the mitochondrial genetics in cancer metastasis: not to be ignored any longer.

2. Metabolic reprogramming of normal oral fibroblasts correlated with increased glycolytic metabolism of oral squamous cell carcinoma and precedes their activation into carcinoma associated fibroblasts.

Review 3. Platelets and extracellular vesicles and their cross talk with cancer.

Review 4. Mitochondrial Retrograde Signalling and Metabolic Alterations in the Tumour Microenvironment.

Review 5. Revisiting Mitochondria Scored Cancer Progression and Metastasis.

Review 6. Roles of mitochondria in the hallmarks of metastasis.

Review 7. Role of Mitochondrial Stress Response in Cancer Progression.

Review 8. Insights regarding mitochondrial DNA copy number alterations in human cancer (Review).