Warning: Undefined array key "mm" in /www/wwwroot/www.ai-bt.com/si.php on line 10 Deprecated: trim(): Passing null to parameter #1 ($string) of type string is deprecated in /www/wwwroot/www.ai-bt.com/si.php on line 10 Adipogenesis inhibitory effects of Limonium tetragonum in mouse bone marrow stromal D1 cells.

Literature DB >> 30263497

Adipogenesis inhibitory effects of Limonium tetragonum in mouse bone marrow stromal D1 cells.

Myeong Sook Kwon¹, Fatih Karadeniz^1,2, Jung-Ae Kim¹, Youngwan Seo^3,4, Chang-Suk Kong^1,2.

Abstract

Unbalanced differentiation of bone marrow cells into adipocytes rather than osteoblasts causes severe bone-related disorders, such as osteoporosis. Natural products that can act against unbalanced differentiation are targeted for development of functional dietary supplements. Limonium tetragonum, a halophyte known for anti-oxidant constituents, was studied for beneficial effects in prevention of adipogenesis of bone marrow stromal D1 cells in vitro. Solvent-partitioned extract fractions of L. tetragonum prevented differentiating D1 cells from accumulating lipids. Expression of the key adipogenic markers PPARγ, SREBP1c, and C/EBPα were inhibited at mRNA and protein levels. Suppressed protein levels of the phosphorylated MAPK-related factors ERK, JNK, and p-38 indicated inhibition of PPARγ pathway-linked adipogenesis in D1 cells. The n-BuOH fraction was the most effective fraction for bioactive substances. L. tetragonum inhibited adipogenesis in D1 bone marrow stromal cells due to the presence of bioactive flavonoids.

Entities: Chemical Disease Species

Keywords: D1 cell; Limonium tetragonum; PPARγ; adipogenesis; bone marrow

Year: 2016 PMID： 30263497 PMCID： PMC6049418 DOI： 10.1007/s10068-016-0109-4

Source DB: PubMed Journal: Food Sci Biotechnol ISSN： 1226-7708 Impact factor: 2.391

14 in total

Review 1. Adipocyte differentiation from the inside out.

Authors: Evan D Rosen; Ormond A MacDougald
Journal: Nat Rev Mol Cell Biol Date: 2006-12 Impact factor: 94.444

2. Glucocorticoid excess in mice results in early activation of osteoclastogenesis and adipogenesis and prolonged suppression of osteogenesis: a longitudinal study of gene expression in bone tissue from glucocorticoid-treated mice.

Authors: Wei Yao; Zhiqiang Cheng; Cheryl Busse; Aaron Pham; Mary C Nakamura; Nancy E Lane
Journal: Arthritis Rheum Date: 2008-06

3. Fatty acids, eicosanoids, and hypolipidemic agents identified as ligands of peroxisome proliferator-activated receptors by coactivator-dependent receptor ligand assay.

Authors: G Krey; O Braissant; F L'Horset; E Kalkhoven; M Perroud; M G Parker; W Wahli
Journal: Mol Endocrinol Date: 1997-06

1. Anticatabolic and Anti-Inflammatory Effects of Myricetin 3-O-β-d-Galactopyranoside in UVA-Irradiated Dermal Cells via Repression of MAPK/AP-1 and Activation of TGFβ/Smad.

Authors: Jung Hwan Oh; Fatih Karadeniz; Jung Im Lee; So Young Park; Youngwan Seo; Chang-Suk Kong
Journal: Molecules Date: 2020-03-14 Impact factor: 4.411

1 in total

Adipogenesis inhibitory effects of Limonium tetragonum in mouse bone marrow stromal D1 cells.

Review 1. Adipocyte differentiation from the inside out.

2. Glucocorticoid excess in mice results in early activation of osteoclastogenesis and adipogenesis and prolonged suppression of osteogenesis: a longitudinal study of gene expression in bone tissue from glucocorticoid-treated mice.

3. Fatty acids, eicosanoids, and hypolipidemic agents identified as ligands of peroxisome proliferator-activated receptors by coactivator-dependent receptor ligand assay.

Review 4. Corticosteroid-induced osteoporosis: an update for dermatologists.

Review 5. Bone marrow, cytokines, and bone remodeling. Emerging insights into the pathophysiology of osteoporosis.

Review 6. Bioavailability, bioactivity and impact on health of dietary flavonoids and related compounds: an update.

7. Evaluation of novel antioxidant triterpenoid saponins from the halophyte Salicornia herbacea.

8. Radical scavenging, antioxidant and antimicrobial activities of halophytic species.

Review 9. Advance in dietary polyphenols as aldose reductases inhibitors: structure-activity relationship aspect.

Review 10. Effects of obesity on bone metabolism.

1. Anticatabolic and Anti-Inflammatory Effects of Myricetin 3-O-β-d-Galactopyranoside in UVA-Irradiated Dermal Cells via Repression of MAPK/AP-1 and Activation of TGFβ/Smad.