Literature DB >> 30263496

Effect of silymarin on gluconeogenesis and lactate production in exercising rats.

Eun-Ju Choi1, Eun-Kyung Kim2, Nam Ho Jeoung3, Sang-Hyun Kim4.   

Abstract

In this study, we investigated the effects of silymarin (SM) on gluconeogenesis during exercise in rats. After 4 weeks of exercise, blood samples, liver, and skeletal muscle tissues were collected, and the levels of triglycerides (TG), lactate, peroxisome proliferator activated receptor gamma (PPARγ), phosphoenol pyruvate carboxykinase (PEPCK), pyruvate dehydrogenase kinase 4 (PDK4), and phosphorylated 5-AMP activated protein kinase (AMPK) were measured. The TG and lactate level of the serum were reduced. In addition, the expression of Akt, PEPCK, and PPARγ in liver was decreased as well as the expression of AMPK in muscle. On the contrary, the level of PDK4 in muscle was increased. These results showed that that administration of SM ameliorated exerciseinduced gluconeogenesis and β-oxidation through the regulation of PPARγ, PEPCK, and PDK4. Thus, intake of SM during exercise may improve endurance by modulating of the metabolism of glucose, lipids, and lactate.

Entities:  

Keywords:  exercise; gluconeogenesis; silymarin; β-oxidation

Year:  2016        PMID： 30263496      PMCID： PMC6049409          DOI： 10.1007/s10068-016-0108-5

Source DB:  PubMed          Journal:  Food Sci Biotechnol        ISSN： 1226-7708            Impact factor:   2.391


  31 in total

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2.  Expression of pyruvate dehydrogenase isoforms during the aerobic/anaerobic transition in the development of the parasitic nematode Ascaris suum: altered stoichiometry of phosphorylation/inactivation.

Authors:  Y J Huang; D Walker; W Chen; M Klingbeil; R Komuniecki
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3.  Basal and insulin-stimulated pyruvate dehydrogenase complex activation, glycogen synthesis and metabolic gene expression in human skeletal muscle the day after a single bout of exercise.

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Journal:  Exp Physiol       Date:  2010-04-09       Impact factor: 2.969

4.  Mitochondrial citric acid cycle and related enzymes: adaptive response to exercise.

Authors:  J O Holloszy; L B Oscai; I J Don; P A Molé
Journal:  Biochem Biophys Res Commun       Date:  1970-09-30       Impact factor: 3.575

5.  Hepatic pyruvate kinase. Quantitative measurements of phosphorylation in vitro and in the isolated rat hepatocyte.

Authors:  J B Blair; M A Cimbala; M E James
Journal:  J Biol Chem       Date:  1982-07-10       Impact factor: 5.157

Review 6.  The use of silymarin in the treatment of liver diseases.

Authors:  R Saller; R Meier; R Brignoli
Journal:  Drugs       Date:  2001       Impact factor: 9.546

7.  Green tea extract selectively activates peroxisome proliferator-activated receptor beta/delta in cultured cardiomyocytes.

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8.  Pyruvate dehydrogenase kinase isoenzyme 4 (PDHK4) deficiency attenuates the long-term negative effects of a high-saturated fat diet.

Authors:  Byounghoon Hwang; Nam Ho Jeoung; Robert A Harris
Journal:  Biochem J       Date:  2009-09-25       Impact factor: 3.857

Review 9.  Metabolic response to exercise.

Authors:  P De Feo; C Di Loreto; P Lucidi; G Murdolo; N Parlanti; A De Cicco; F Piccioni; F Santeusanio
Journal:  J Endocrinol Invest       Date:  2003-09       Impact factor: 4.256

10.  Normal insulin response to short-term intense exercise is abolished in Type 2 diabetic patients treated with gliclazide.

Authors:  Jan Szewieczek; Jan Dulawa; Dorota Strzałkowska; Agnieszka Batko-Szwaczka; Beata Hornik
Journal:  J Diabetes Complications       Date:  2008-04-03       Impact factor: 2.852
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  3 in total

1.  Hepatoprotective Effects of Silymarin on Liver Injury via Irisin Upregulation and Oxidative Stress Reduction in Rats with Type 2 Diabetes.

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Review 2.  Flavolignans from Silymarin as Nrf2 Bioactivators and Their Therapeutic Applications.

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Journal:  Biomedicines       Date:  2020-05-14

3.  Effect of Silymarin Supplementation on Physical Performance, Muscle and Myocardium Histological Changes, Bodyweight, and Food Consumption in Rats Subjected to Regular Exercise Training.

Authors:  Nancy Vargas-Mendoza; Marcelo Ángeles-Valencia; Eduardo Osiris Madrigal-Santillán; Mauricio Morales-Martínez; Judith Margarita Tirado-Lule; Arturo Solano-Urrusquieta; Eduardo Madrigal-Bujaidar; Isela Álvarez-González; Tomás Fregoso-Aguilar; Ángel Morales-González; José A Morales-González
Journal:  Int J Mol Sci       Date:  2020-10-19       Impact factor: 5.923
  3 in total

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