Literature DB >> 30263426

Lipid-lowering effects of Zanthoxylum schinifolium Siebold & Zucc. seed oil (ZSO) in hyperlipidemic rats and lipolytic effects in 3T3-L1 adipocytes.

Kyoung Kon Kim1, Tae Woo Kim2, Yun Hwan Kang3, Dae Jung Kim2, Myeon Choe1,2.   

Abstract

On the basis of the antiatherosclerotic effect of Zanthoxylum schinifolium, the therapeutic potential of Zanthoxylum schinifolium seed oil (ZSO) was tested in terms of the blood lipid profile and obesity in rats. The lipolytic effects of ZSO were determined in adipocytes and the total body and liver weight were decreased in rats. Compared with the high-cholesterol high-fat (HCHF) group, the rats in the HCHF+ZSO group showed improved levels of hyperlipidemia indicators. Furthermore, western blot analysis confirmed that the improvement of hyperlipidemia indicators was induced by stimulation of lipoprotein lipase expression. Additional results indicated that the reduction in body weight was likely caused by phosphorylation of hormone-sensitive lipase (HSL) via the protein kinase A pathway, ultimately leading to lipolysis. In conclusion, the results of the in vivo experiment showed that ZSO improved the lipid profiles in the blood, lowering cardiovascular disease and arteriosclerosis and degrading cellular lipids by activating HSL.

Entities:  

Keywords:  Zanthoxylum schinifolium Siebold & Zucc; hormone-sensitive lipase; hyperlipidemia; lipolysis; protein kinase A; seed oil

Year:  2016        PMID： 30263426      PMCID： PMC6049273          DOI： 10.1007/s10068-016-0222-4

Source DB:  PubMed          Journal:  Food Sci Biotechnol        ISSN： 1226-7708            Impact factor:   2.391


  22 in total

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Review 4.  Regulation of triglyceride metabolism. IV. Hormonal regulation of lipolysis in adipose tissue.

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5.  Severe hypertriglyceridemia, reduced high density lipoprotein, and neonatal death in lipoprotein lipase knockout mice. Mild hypertriglyceridemia with impaired very low density lipoprotein clearance in heterozygotes.

Authors:  P H Weinstock; C L Bisgaier; K Aalto-Setälä; H Radner; R Ramakrishnan; S Levak-Frank; A D Essenburg; R Zechner; J L Breslow
Journal:  J Clin Invest       Date:  1995-12       Impact factor: 14.808

6.  Anti-hyperlipidemic and cardioprotective effects of Ocimum sanctum L. fixed oil in rats fed a high fat diet.

Authors:  Thamolwan Suanarunsawat; Theewara Boonnak; Watcharaporn Devakul Na Ayutthaya; Suwan Thirawarapan
Journal:  J Basic Clin Physiol Pharmacol       Date:  2010

7.  Activity of hepatic fatty acid oxidation enzymes in rats fed alpha-linolenic acid.

Authors:  Y Kabir; T Ide
Journal:  Biochim Biophys Acta       Date:  1996-11-22

8.  Suppression of adipocyte hypertrophy by polymethoxyflavonoids isolated from Kaempferia parviflora.

Authors:  Yui Okabe; Tsutomu Shimada; Takumi Horikawa; Kaoru Kinoshita; Kiyotaka Koyama; Koji Ichinose; Masaki Aburada; Kunio Takahashi
Journal:  Phytomedicine       Date:  2014-03-11       Impact factor: 5.340

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Authors:  C Holm
Journal:  Biochem Soc Trans       Date:  2003-12       Impact factor: 5.407

10.  Effects of Oils and Essential Oils from Seeds of Zanthoxylum schinifolium against Foodborne Viral Surrogates.

Authors:  Mi Oh; Mi Sook Chung
Journal:  Evid Based Complement Alternat Med       Date:  2014-12-18       Impact factor: 2.629
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  1 in total

1.  Induction of apoptotic cell death in human bladder cancer cells by ethanol extract of Zanthoxylum schinifolium leaf, through ROS-dependent inactivation of the PI3K/Akt signaling pathway.

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Journal:  Nutr Res Pract       Date:  2021-12-08       Impact factor: 1.992
  1 in total

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