| Literature DB >> 30263401 |
Ganiyu Oboh1, Ayodele Jacob Akinyemi1,2, Blessing Adeleye1, Sunday Idowu Oyeleye1,3, Opeyemi Babatunde Ogunsuyi1,3, Ayokunle Olubode Ademosun1, Adedayo Oluwaseun Ademiluyi1, Aline Augusti Boligon4.
Abstract
This study compared the phenolic compositions of common green leafy vegetable extracts from Vernonia amygdalina (VA), Telfairia occidentalis (TO), Talinium triangulare (TT), and Amaranthus hybridus (AH) and their effects on the angiotensin-I-converting enzyme (ACE) and cisplatin-induced malonylaldehyde (MDA) production in an isolated rat kidney homogenate. HPLC confirmed the presence of phenolic compounds in the extracts. Furthermore, all extracts inhibited ACE activity dosedependently; however, the extract from VA exhibited the highest ACE activity while TT exhibited the least. Incubation of the kidney homogenate with 1mM cisplatin caused an increase in MDA production; however, all the extracts inhibited the level of MDA produced. Nevertheless, VA extract exhibited the highest inhibition. These activities of the vegetable extracts could be attributed to their phenolic compositions and may suggest some possible mechanism of the actions. However, VA appeared to be the most potent among the vegetables tested.Entities:
Keywords: angiotensin-I-converting enzyme; oxidative stress; polyphenolic; renal damage; vegetables
Year: 2016 PMID： 30263401 PMCID： PMC6049283 DOI： 10.1007/s10068-016-0197-1
Source DB: PubMed Journal: Food Sci Biotechnol ISSN： 1226-7708 Impact factor: 2.391