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Literature DB >> 30263387

Lithium chloride's inhibition of 3T3-L1 cell differentiation by regulating the Wnt/β-catenin pathway and enhancing villin 2 expression.

Yu-Yang Chi¹, Jing-Lin Shen¹, Jing Zhang¹, An-Shan Shan², Shu-Ling Niu¹, Chang-Hai Zhou¹, Hong-Gu Lee³, Yong-Cheng Jin¹.

Abstract

The aim of this study is to reveal the relation among villin 2, Wnt/β-catenin, and adipogenesis by adding appropriate lithium chloride (LiCl). The study comprises three parts: the selection of LiCl concentration, the effect of LiCl on adipocyte differentiation during and after differentiation induction. By comprehensively analyzing the results of the experiments, we proved that LiCl can inhibit adipocyte differentiation and enhance villin 2 and β-catenin expressions not only during differentiation induction but also after it. Moreover, villin 2 has a significant impact on β-catenin. We suggest that villin 2 may participate in Wnt/β-catenin signaling.

Entities: Chemical Gene

Keywords: 3T3-L1; adipocyte differentiation; lithium chloride; villin 2; β-catenin

Year: 2016 PMID： 30263387 PMCID： PMC6049105 DOI： 10.1007/s10068-016-0183-7

Source DB: PubMed Journal: Food Sci Biotechnol ISSN： 1226-7708 Impact factor: 2.391

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