Literature DB >> 30263314

Effects of Allium hookeri root water extracts on inhibition of adipogenesis and GLUT-4 expression in 3T3-L1 adipocytes.

Hee Sun Yang1, Yu Jin Choi1, Hee Yeon Jin1, Sang Cheon Lee1, Chang Ki Huh1.   

Abstract

Anti-adipogenic and antidiabetic activities of Allium hookeri root water extracts (ARW) were assessed. Oil Red O staining showed that treatment with ARW caused a dose-dependent reduction in lipid accumulation. ARW was also involved in adipocyte lipolysis via LPL activity, and in the concentration of glycerol in a culture medium. On the basis of the concentration of adipokines following ARW treatment, ARW appeared to inhibit expression of PPAR-γ, to reduce concentrations of leptin and resistin, to increase the concentration of adiponectin, and to inhibit lipid accumulation. ARW modulated adipokine expression associated with insulin resistance and sensitivity. 3T3-L1 adipocytes treated with ARW showed increased GLUT-4 expression with increased glucose uptake into adipocytes. ARW showed effectiveness for improvement of diabetic conditions.

Entities:  

Keywords:  3T3-L1; Allium hookeri; GLUT-4; adipogenesis

Year:  2016        PMID： 30263314      PMCID： PMC6049204          DOI： 10.1007/s10068-016-0086-7

Source DB:  PubMed          Journal:  Food Sci Biotechnol        ISSN： 1226-7708            Impact factor:   2.391


  24 in total

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  6 in total

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