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Literature DB >> 3026311

Conformational transitions in the Ca2+ + Mg2+-activated ATPase and the binding of Ca2+ ions.

Abstract

We have studied the fluorescence of the Ca2+ + Mg2+-activated ATPase of sarcoplasmic reticulum labelled with fluorescein isothiocyanate. The change in intensity of fluorescein fluorescence caused by addition of Ca2+ to the labelled ATPase can be interpreted in terms of a two-conformation model for the ATPase, one conformation (E1) having a high affinity for Ca2+, the other (E2) a low affinity. Effects of Ca2+ as a function of pH allow an estimate of the effect of pH on the E1/E2 ratio, consistent with kinetic studies. A model is presented for binding of Ca2+ to the ATPase as a function of pH that is consistent both with the data on the E1/E2 equilibrium and with literature data on Ca2+ binding.

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Year: 1986 PMID： 3026311 PMCID： PMC1146966 DOI： 10.1042/bj2370197

Source DB: PubMed Journal: Biochem J ISSN： 0264-6021 Impact factor: 3.857

36 in total

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Authors: R M Chaloub; H Guimaraes-Motta; S Verjovski-Almeida; L de Meis; G Inesi
Journal: J Biol Chem Date: 1979-10-10 Impact factor: 5.157

Review 2. Energy interconversion by the Ca2+-dependent ATPase of the sarcoplasmic reticulum.

Authors: L de Meis; A L Vianna
Journal: Annu Rev Biochem Date: 1979 Impact factor: 23.643

3. Transient kinetics of sarcoplasmic reticulum CA2+ + Mg2+ ATPase studied by fluorescence.

Authors: Y Dupont; J B Leigh
Journal: Nature Date: 1978-06-01 Impact factor: 49.962

4. Reconstitution of a calcium pump using defined membrane components.

Authors: G B Warren; P A Toon; N J Birdsall; A G Lee; J C Metcalfe
Journal: Proc Natl Acad Sci U S A Date: 1974-03 Impact factor: 11.205

5. ATP and Ca2+ binding by the Ca2+ pump protein of sarcoplasmic reticulum.

Authors: G Meissner
Journal: Biochim Biophys Acta Date: 1973-04-16

6. Reversible lipid titrations of the activity of pure adenosine triphosphatase-lipid complexes.

Authors: G B Warren; P A Toon; N J Birdsall; A G Lee; J C Metcalfe
Journal: Biochemistry Date: 1974-12-31 Impact factor: 3.162

7. Effect of K+ on phosphorylation of the sarcoplasmic reticulum ATPase by either Pi or ATP.

Authors: R M Chaloub; L de Meis
Journal: J Biol Chem Date: 1980-07-10 Impact factor: 5.157

8. A direct fluorescence study of the transient steps induced by calcium binding to sarcoplasmic reticulum ATPase.

Authors: F Guillain; M P Gingold; S Büschlen; P Champeil
Journal: J Biol Chem Date: 1980-03-10 Impact factor: 5.157

9. Modification of the ATP binding site of the Ca2+ -ATPase from sarcoplasmic reticulum by fluorescein isothiocyanate.

Authors: U Pick; S Bassilian
Journal: FEBS Lett Date: 1981-01-12 Impact factor: 4.124

10. Indications for an oligomeric structure and for conformational changes in sarcoplasmic reticulum Ca2+-ATPase labelled selectively with fluorescein.

Authors: U Pick; S J Karlish
Journal: Biochim Biophys Acta Date: 1980-11-20

24 in total

Review 1. What the structure of a calcium pump tells us about its mechanism.

Authors: A G Lee; J M East
Journal: Biochem J Date: 2001-06-15 Impact factor: 3.857

2. Cytoplasmic interactions between phospholamban residues 1-20 and the calcium-activated ATPase of the sarcoplasmic reticulum.

Authors: P Sharma; V B Patchell; Y Gao; J S Evans; B A Levine
Journal: Biochem J Date: 2001-05-01 Impact factor: 3.857

3. An autoinhibitory peptide from the erythrocyte Ca-ATPase aggregates and inhibits both muscle Ca-ATPase isoforms.

Authors: L G Reddy; Y Shi; H Kutchai; A G Filoteo; J T Penniston; D D Thomas
Journal: Biophys J Date: 1999-06 Impact factor: 4.033

4. Definition of surface-exposed and trans-membranous regions of the (Ca(2+)-Mg2+)-ATPase of sarcoplasmic reticulum using anti-peptide antibodies.

Authors: A M Mata; I Matthews; R E Tunwell; R P Sharma; A G Lee; J M East
Journal: Biochem J Date: 1992-09-01 Impact factor: 3.857

5. Mechanism of inhibition of the calcium pump of sarcoplasmic reticulum by thapsigargin.

Authors: M Wictome; I Henderson; A G Lee; J M East
Journal: Biochem J Date: 1992-04-15 Impact factor: 3.857

6. Identification, kinetic properties and intracellular localization of the (Ca(2+)-Mg2+)-ATPase from the intracellular stores of chicken cerebellum.

Authors: F Michelangeli; F Di Virgilio; A Villa; P Podini; J Meldolesi; T Pozzan
Journal: Biochem J Date: 1991-05-01 Impact factor: 3.857

7. Effects on ATPase activity of monoclonal antibodies raised against (Ca2+ + Mg2+)-ATPase from rabbit skeletal muscle sarcoplasmic reticulum and their correlation with epitope location.

Authors: J Colyer; A M Mata; A G Lee; J M East
Journal: Biochem J Date: 1989-09-01 Impact factor: 3.857

Review 8. Interactions of lipids and proteins: some general principles.

Authors: A G Lee
Journal: J Bioenerg Biomembr Date: 1987-12 Impact factor: 2.945

9. Inactivation of sarcoplasmic-reticulum Ca(2+)-ATPase in low-frequency-stimulated muscle results from a modification of the active site.

Authors: S Matsushita; D Pette
Journal: Biochem J Date: 1992-07-01 Impact factor: 3.857

10. Characterization of the single Ca(2+)-binding site on the Ca(2+)-ATPase reconstituted with short- or long-chain phosphatidylcholines.

Authors: A P Starling; Y M Khan; J M East; A G Lee
Journal: Biochem J Date: 1994-12-01 Impact factor: 3.857