Jean M Donnelly1, Karen Lindsay1, Jennifer M Walsh1, Mary K Horan1, Donal O'Shea2, Eleanor J Molloy3,4,5, Fionnuala M McAuliffe1. 1. UCD Obstetrics and Gynecology, School of Medicine and Medical Science, University College Dublin, National Maternity Hospital, Dublin, Ireland. 2. School of Medicine and Medical Science, St. Vincent's Hospital, Dublin, Ireland. 3. Department of Paediatrics, University of Dublin, Dublin, Ireland. 4. Department of Neonatology, Our Lady's Children's Hospital, Crumlin, Ireland. 5. Department of Neonatology, Coombe Women and Infants Hospital, Dublin, Ireland.
Abstract
Background: To determine the association of maternal and fetal inflammatory factors with gender-specific infant adiposity, independent of leptin. Methods: Analysis of anthropometry from 265 mother-infant pairs at birth and 280 pairs at 6 months from the randomised control trial of low glycaemic index diet in pregnancy (ROLO) study (Randomised control trial of low glycaemic index diet) and their association with Maternal TNF-alpha, interleukin 6 and leptin as measured in early and late pregnancy and fetal levels in cord blood. Results: No associations were noted in the male cohort. On multiple regression amongst the female neonatal cohort late pregnancy IL-6 was inversely associated with sum of skinfolds (p ≤ .001); at 6 months infant sum of skinfolds were positively associated with early pregnancy IL-6 (p = .046) and central adiposity positively associated with early pregnancyTNF alpha (p = .018) independent of leptin. Conclusion: Although maternal inflammatory cytokines were not associated with neonatal adiposity independent of leptin (as this association is known), both IL-6 and TNF-α were associated with female infant anthropometry at 6 months of age independent of leptin. These results suggest inflammatory cytokines may exert an in-utero influence on later infant adiposity with a tendency to influence female adiposity more than male. Further research is required to ascertain whether these cytokines may be used as reliable early predictors of infant adiposity.
RCT Entities:
Background: To determine the association of maternal and fetal inflammatory factors with gender-specific infant adiposity, independent of leptin. Methods: Analysis of anthropometry from 265 mother-infant pairs at birth and 280 pairs at 6 months from the randomised control trial of low glycaemic index diet in pregnancy (ROLO) study (Randomised control trial of low glycaemic index diet) and their association with Maternal TNF-alpha, interleukin 6 and leptin as measured in early and late pregnancy and fetal levels in cord blood. Results: No associations were noted in the male cohort. On multiple regression amongst the female neonatal cohort late pregnancy IL-6 was inversely associated with sum of skinfolds (p ≤ .001); at 6 months infant sum of skinfolds were positively associated with early pregnancy IL-6 (p = .046) and central adiposity positively associated with early pregnancy TNF alpha (p = .018) independent of leptin. Conclusion: Although maternal inflammatory cytokines were not associated with neonatal adiposity independent of leptin (as this association is known), both IL-6 and TNF-α were associated with female infant anthropometry at 6 months of age independent of leptin. These results suggest inflammatory cytokines may exert an in-utero influence on later infant adiposity with a tendency to influence female adiposity more than male. Further research is required to ascertain whether these cytokines may be used as reliable early predictors of infant adiposity.
Entities:
Keywords:
IL-6; TNFα; in utero; inflammation; offspring
Authors: Melissa E Heard-Lipsmeyer; Eva C Diaz; Clark R Sims; Sarah R Sobik; Meghan L Ruebel; Keshari M Thakali; Rebecca A Krukowski; Mario Cleves; Elisabet Børsheim; Kartik Shankar; Aline Andres Journal: Obesity (Silver Spring) Date: 2020-02-06 Impact factor: 5.002
Authors: H C Bartels; A A Geraghty; E C O'Brien; A Kranidi; J Mehegan; C Yelverton; C M McDonnell; F M McAuliffe Journal: J Nutr Metab Date: 2020-09-23