Literature DB >> 30261290

Dietary nitrate's effects on exercise performance in heart failure with reduced ejection fraction (HFrEF).

Vinaya Mulkareddy1, Susan B Racette2, Andrew R Coggan3, Linda R Peterson4.   

Abstract

Heart failure with reduced ejection fraction (HFrEF) is a deadly and disabling disease. A key derangement contributing to impaired exercise performance in HFrEF is decreased nitric oxide (NO) bioavailability. Scientists recently discovered the inorganic nitrate pathway for increasing NO. This has advantages over organic nitrates and NO synthase production of NO. Small studies using beetroot juice as a source of inorganic nitrate demonstrate its power to improve exercise performance in HFrEF. A larger-scale trial is now underway to determine if inorganic nitrate may be a new arrow for physicians' quiver of HFrEF treatments.
Copyright © 2018 Elsevier B.V. All rights reserved.

Entities:  

Keywords:  Exercise performance; Heart failure; Inorganic nitrate; Muscle power; Nitric oxide; Peak oxygen consumption

Mesh：

Substances：

Year:  2018        PMID： 30261290      PMCID： PMC6401215          DOI： 10.1016/j.bbadis.2018.09.026

Source DB:  PubMed          Journal:  Biochim Biophys Acta Mol Basis Dis        ISSN： 0925-4439            Impact factor:   5.187


  51 in total

1.  Skeletal muscle as an endogenous nitrate reservoir.

Authors:  Barbora Piknova; Ji Won Park; Kathryn M Swanson; Soumyadeep Dey; Constance Tom Noguchi; Alan N Schechter
Journal:  Nitric Oxide       Date:  2015-02-26       Impact factor: 4.427

Review 2.  The nitrate-nitrite-nitric oxide pathway in physiology and therapeutics.

Authors:  Jon O Lundberg; Eddie Weitzberg; Mark T Gladwin
Journal:  Nat Rev Drug Discov       Date:  2008-02       Impact factor: 84.694

3.  Modulation of contractile apparatus Ca2+ sensitivity and disruption of excitation-contraction coupling by S-nitrosoglutathione in rat muscle fibres.

Authors:  T L Dutka; J P Mollica; G S Posterino; G D Lamb
Journal:  J Physiol       Date:  2010-11-29       Impact factor: 5.182

4.  Dietary nitrate supplementation and exercise tolerance in patients with heart failure with reduced ejection fraction.

Authors:  Daniel M Hirai; Joel T Zelt; Joshua H Jones; Luiza G Castanhas; Robert F Bentley; Wendy Earle; Patti Staples; Michael E Tschakovsky; John McCans; Denis E O'Donnell; J Alberto Neder
Journal:  Am J Physiol Regul Integr Comp Physiol       Date:  2016-10-26       Impact factor: 3.619

5.  Nitrite therapy improves left ventricular function during heart failure via restoration of nitric oxide-mediated cytoprotective signaling.

Authors:  Shashi Bhushan; Kazuhisa Kondo; David J Polhemus; Hiroyuki Otsuka; Chad K Nicholson; Ya-Xiong Tao; Hui Huang; Vasiliki V Georgiopoulou; Toyoaki Murohara; John W Calvert; Javed Butler; David J Lefer
Journal:  Circ Res       Date:  2014-03-05       Impact factor: 17.367

6.  Mechanisms underlying skeletal muscle weakness in human heart failure: alterations in single fiber myosin protein content and function.

Authors:  Mark S Miller; Peter Vanburen; Martin M Lewinter; Stewart H Lecker; Donald E Selby; Bradley M Palmer; David W Maughan; Philip A Ades; Michael J Toth
Journal:  Circ Heart Fail       Date:  2009-09-24       Impact factor: 8.790

7.  Dietary nitrate reduces maximal oxygen consumption while maintaining work performance in maximal exercise.

Authors:  Filip J Larsen; Eddie Weitzberg; Jon O Lundberg; Björn Ekblom
Journal:  Free Radic Biol Med       Date:  2009-11-12       Impact factor: 7.376

8.  Muscular strength in male adolescents and premature death: cohort study of one million participants.

Authors:  Francisco B Ortega; Karri Silventoinen; Per Tynelius; Finn Rasmussen
Journal:  BMJ       Date:  2012-11-20

9.  Nitrate enhances skeletal muscle fatty acid oxidation via a nitric oxide-cGMP-PPAR-mediated mechanism.

Authors:  Tom Ashmore; Lee D Roberts; Andrea J Morash; Aleksandra O Kotwica; John Finnerty; James A West; Steven A Murfitt; Bernadette O Fernandez; Cristina Branco; Andrew S Cowburn; Kieran Clarke; Randall S Johnson; Martin Feelisch; Julian L Griffin; Andrew J Murray
Journal:  BMC Biol       Date:  2015-12-22       Impact factor: 7.431

10.  Skeletal muscle molecular alterations precede whole-muscle dysfunction in NYHA Class II heart failure patients.

Authors:  Michael P Godard; Samantha A Whitman; Yao-Hua Song; Patrice Delafontaine
Journal:  Clin Interv Aging       Date:  2012-11-12       Impact factor: 4.458
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  3 in total

1.  Sex Differences Across the Lifespan: A Focus on Cardiometabolism.

Authors:  T Rajendra Kumar; Jane E B Reusch; Wendy M Kohrt; Judith G Regensteiner
Journal:  J Womens Health (Larchmt)       Date:  2020-05-17       Impact factor: 2.681

Review 2.  Skeletal Muscle Contractile Function in Heart Failure With Reduced Ejection Fraction-A Focus on Nitric Oxide.

Authors:  Lauren K Park; Andrew R Coggan; Linda R Peterson
Journal:  Front Physiol       Date:  2022-06-01       Impact factor: 4.755

3.  Inorganic nitrate, hypoxia, and the regulation of cardiac mitochondrial respiration-probing the role of PPARα.

Authors:  James A Horscroft; Katie A O'Brien; Anna D Clark; Ross T Lindsay; Alice Strang Steel; Nathan E K Procter; Jules Devaux; Michael Frenneaux; Stephen D R Harridge; Andrew J Murray
Journal:  FASEB J       Date:  2019-03-14       Impact factor: 5.834
  3 in total

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