Batchimeg Tsedenbal1, Tomomi Yoshida2, Bayarmaa Enkhbat3, Uyanga Gotov4, Enkhtuya Sharkhuu5, Masanao Saio6, Toshio Fukuda7. 1. Graduate School of Health Sciences, Gunma University, 3-39-22 Showa-machi, Maebashi, Gunma 371-8514, Japan; Mongolian National University of Medical Sciences, Jamyan St 3, Sukhbaatar District, Ulaanbaatar 14210, Mongolia. Electronic address: batchimeg.ts@mnums.edu.mn. 2. Graduate School of Health Sciences, Gunma University, 3-39-22 Showa-machi, Maebashi, Gunma 371-8514, Japan. Electronic address: tomorepa@gunma-u.ac.jp. 3. Mongolian National University of Medical Sciences, Jamyan St 3, Sukhbaatar District, Ulaanbaatar 14210, Mongolia. Electronic address: bayarmaa.e@mnums.edu.mn. 4. National Center for Pathology, Ministry of Health, 1st Khoroo, Sukhbaatar District, Ulaanbaatar 14210, Mongolia. Electronic address: uyangagotov@gmail.com. 5. Mongolian Association of Histopathology and Cytopathology, Nam Yan Ju Street, Bayanzurkh District, Ulaanbaatar 13374, Mongolia. Electronic address: cancer_enkh@yahoo.com. 6. Graduate School of Health Sciences, Gunma University, 3-39-22 Showa-machi, Maebashi, Gunma 371-8514, Japan. Electronic address: saio@gunma-u.ac.jp. 7. Graduate School of Health Sciences, Gunma University, 3-39-22 Showa-machi, Maebashi, Gunma 371-8514, Japan. Electronic address: fukuda@gunma-u.ac.jp.
Abstract
OBJECTIVES: Few studies on human papillomavirus (HPV) have been conducted in Mongolia. This study was performed to evaluate the prevalent HPV genotypes and their associations with cytology and demographic and behavioral characteristics in Mongolian women with cervical abnormalities. METHODS: Exfoliated cell samples of 100 women who had a previous history of cervical abnormality were collected. Cytological interpretation was conducted microscopically and HPV genotyping was performed using the Roche Linear Array test. Study questionnaires were completed. RESULTS: Overall, 25 HPV genotypes were detected in 47% of participants, and the most prevalent were HPV 16, 52, 58, and 33. Cytological examination revealed 12% of participants had atypical squamous cells of undetermined significance (ASC-US), 8% had low-grade squamous intraepithelial lesions (LSIL), 7% had high-grade squamous intraepithelial lesions (HSIL), and 14% had squamous cell carcinoma (SCC), while 59% of women had a normal cytology. HPV 16 was the most common type among women with a normal cytology and cervical cancer. However, women with cervical abnormalities including LSIL and HSIL were predominantly infected with HPV 52. Moreover, women aged <35 years had a significantly higher risk of HPV infection than those in the other age groups (p<0.05). CONCLUSIONS: The prevalent trend of HPV genotypes observed in this cohort differs from that reported previously in Mongolia. These data may contribute to developing an effective strategy for cervical cancer prevention in Mongolia.
OBJECTIVES: Few studies on human papillomavirus (HPV) have been conducted in Mongolia. This study was performed to evaluate the prevalent HPV genotypes and their associations with cytology and demographic and behavioral characteristics in Mongolian women with cervical abnormalities. METHODS: Exfoliated cell samples of 100 women who had a previous history of cervical abnormality were collected. Cytological interpretation was conducted microscopically and HPV genotyping was performed using the Roche Linear Array test. Study questionnaires were completed. RESULTS: Overall, 25 HPV genotypes were detected in 47% of participants, and the most prevalent were HPV 16, 52, 58, and 33. Cytological examination revealed 12% of participants had atypical squamous cells of undetermined significance (ASC-US), 8% had low-grade squamous intraepithelial lesions (LSIL), 7% had high-grade squamous intraepithelial lesions (HSIL), and 14% had squamous cell carcinoma (SCC), while 59% of women had a normal cytology. HPV 16 was the most common type among women with a normal cytology and cervical cancer. However, women with cervical abnormalities including LSIL and HSIL were predominantly infected with HPV 52. Moreover, women aged <35 years had a significantly higher risk of HPV infection than those in the other age groups (p<0.05). CONCLUSIONS: The prevalent trend of HPV genotypes observed in this cohort differs from that reported previously in Mongolia. These data may contribute to developing an effective strategy for cervical cancer prevention in Mongolia.
Authors: Li Song; Yuanjing Lyu; Ling Ding; Xiaoxue Li; Wen Gao; Ming Wang; Min Hao; Zhilian Wang; Jintao Wang Journal: Cancer Manag Res Date: 2020-12-08 Impact factor: 3.989