Literature DB >> 30261239

Antifungal activity of octenidine dihydrochloride and ultraviolet-C light against multidrug-resistant Candida auris.

P Ponnachan1, V Vinod2, U Pullanhi3, P Varma4, S Singh5, R Biswas2, A Kumar6.   

Abstract

Outbreaks due to multidrug-resistant Candida auris have emerged as a large threat to modern medicine. Since skin colonization and environmental contamination have been identified as a precursor for outbreaks, we evaluated the antifungal activity of ultraviolet-C light using mercury vapour lamp with a peak emission of 254 ± 2 nm and octenidine dihydrochloride against C. auris clinical isolates. Octenidine dihydrochloride was found effective at significantly lower concentrations (0.00005-0.0004%) than those currently used in the clinical setting (0.05-0.1%). Scanning electron microscopy images show destruction of the organism within 6 h of exposure to 0.0005% octenidine dihydrochloride. Ultraviolet-C light could kill all C. auris with 15 min exposure.
Copyright © 2018 The Healthcare Infection Society. Published by Elsevier Ltd. All rights reserved.

Entities:  

Keywords:  Candida auris; Colonization; Disinfection; Octenidine dihydrochloride; Ultraviolet-C

Mesh：

Substances：

Year:  2018        PMID： 30261239     DOI： 10.1016/j.jhin.2018.09.008

Source DB:  PubMed          Journal:  J Hosp Infect        ISSN： 0195-6701            Impact factor:   3.926


  8 in total

1.  Eco-Friendly and Systematic Study for Synthesis of La3+/α-Al2O3 Nanoparticles: Antibacterial Activity Against Pathogenic Microbial Strains.

Authors:  Mohammad Hasan Moshafi; Mehdi Ranjbar; Ghazaleh Ilbeigi
Journal:  Int J Nanomedicine       Date:  2019-12-30

2.  Evaluating the measures taken to contain a Candida auris outbreak in a tertiary care hospital in South India: an outbreak investigational study.

Authors:  Dipu Thareparambil Sathyapalan; Remya Antony; Vrinda Nampoothiri; Anil Kumar; Nandita Shashindran; Jini James; Jisha Thomas; Preetha Prasanna; Akkulath Sangita Sudhir; Jeslyn Mary Philip; Fabia Edathadathil; Binny Prabhu; Sanjeev Singh; Merlin Moni
Journal:  BMC Infect Dis       Date:  2021-05-06       Impact factor: 3.090

3.  Killing of Candida auris by UV-C: Importance of exposure time and distance.

Authors:  Theun de Groot; Anuradha Chowdhary; Jacques F Meis; Andreas Voss
Journal:  Mycoses       Date:  2019-03-12       Impact factor: 4.377

Review 4.  Candida auris: Epidemiology, Diagnosis, Pathogenesis, Antifungal Susceptibility, and Infection Control Measures to Combat the Spread of Infections in Healthcare Facilities.

Authors:  Suhail Ahmad; Wadha Alfouzan
Journal:  Microorganisms       Date:  2021-04-11

5.  Shining light on multi-drug resistant Candida auris: Ultraviolet-C disinfection, wavelength sensitivity, and prevention of biofilm formation of an emerging yeast pathogen.

Authors:  Richard M Mariita; James H Davis; Michelle M Lottridge; Rajul V Randive
Journal:  Microbiologyopen       Date:  2022-02       Impact factor: 3.139

6.  Comparative Fungicidal Activities of N-Chlorotaurine and Conventional Antiseptics against Candida spp. Isolated from Vulvovaginal Candidiasis.

Authors:  Mayram Hacioglu; Ozlem Oyardi; Fatima Nur Yilmaz; Markus Nagl
Journal:  J Fungi (Basel)       Date:  2022-06-28

Review 7.  Promising Drug Candidates and New Strategies for Fighting against the Emerging Superbug Candida auris.

Authors:  Muriel Billamboz; Zeeshan Fatima; Saif Hameed; Samir Jawhara
Journal:  Microorganisms       Date:  2021-03-18

8.  The use of a UV-C disinfection robot in the routine cleaning process: a field study in an Academic hospital.

Authors:  Füszl Astrid; Zatorska Beata; Ebner Julia; Presterl Elisabeth; Diab-Elschahawi Magda
Journal:  Antimicrob Resist Infect Control       Date:  2021-05-29       Impact factor: 4.887
  8 in total

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