Wen-Feng Li1, Yu-Qing Huang2, Ying-Qing Feng1,2. 1. The Second School of Clinical Medicine, Southern Medical University. 2. Hypertension Research Laboratory, Guangdong Provincial Key Laboratory of Coronary Disease Prevention, Department of Cardiology, School of Medicine, Guangdong Cardiovascular Institute, Guangdong General Hospital, Guangdong Academy of Medical Sciences, South China University of Technology, Guangzhou, China.
Abstract
BACKGROUND: Oxygen therapy is widely used for patients with acute myocardial infarction (AMI). However, there is uncertainty about its safety and benefits. The aim of this study is to perform a systematic review and meta-analysis to assess the effectiveness and safety of oxygen therapy for patients with AMI. MATERIALS AND METHODS: We searched MEDLINE, CINAHL, EMBASE, Cochrane Central Register of Controlled Trials from 1 January 1967, through 31 December 2017. We included randomized controlled clinical trials that used oxygen therapy for patients with suspected or confirmed AMI less than 24 h of symptoms onset. Hyperbaric and aqueous oxygen therapy trials were excluded. RESULTS: A total of six randomized controlled clinical trials with 7190 individuals were included in this meta-analysis. Compared with no oxygen group, oxygen therapy did not reduce the risk of all-cause mortality [pooled risk ratio (RR): 1.06, 95% confidence interval (CI): 0.56-2.02, P=0.19], recurrent myocardial infarction (pooled RR: 1.57, 95% CI: 0.88-2.80, P=0.18), and pain (pooled RR: 0.97, 95% CI: 0.82-1.14, P=0.25). CONCLUSION: In this meta-analysis, oxygen inhalation did not benefit patients with AMI with normal oxygen saturation.
BACKGROUND:Oxygen therapy is widely used for patients with acute myocardial infarction (AMI). However, there is uncertainty about its safety and benefits. The aim of this study is to perform a systematic review and meta-analysis to assess the effectiveness and safety of oxygen therapy for patients with AMI. MATERIALS AND METHODS: We searched MEDLINE, CINAHL, EMBASE, Cochrane Central Register of Controlled Trials from 1 January 1967, through 31 December 2017. We included randomized controlled clinical trials that used oxygen therapy for patients with suspected or confirmed AMI less than 24 h of symptoms onset. Hyperbaric and aqueous oxygen therapy trials were excluded. RESULTS: A total of six randomized controlled clinical trials with 7190 individuals were included in this meta-analysis. Compared with no oxygen group, oxygen therapy did not reduce the risk of all-cause mortality [pooled risk ratio (RR): 1.06, 95% confidence interval (CI): 0.56-2.02, P=0.19], recurrent myocardial infarction (pooled RR: 1.57, 95% CI: 0.88-2.80, P=0.18), and pain (pooled RR: 0.97, 95% CI: 0.82-1.14, P=0.25). CONCLUSION: In this meta-analysis, oxygen inhalation did not benefit patients with AMI with normal oxygen saturation.