Literature DB >> 30260344

A novel guanine N3 alkylation by antitumor antibiotic duocarmycin A.

H Sugiyama1, K Ohmori, K L Chan, M Hosoda, A Asai, H Saito, I Saito.   

Abstract

Antitumor antibiotic duocarmycin A was found to undergo a novel N3 alkylation of the guanine residue (G7) of d(GCAATTGC)2. Guanine base was shown to be a second major target of duocarmycin A in DNA.

Entities:  

Year:  1993        PMID: 30260344

Source DB:  PubMed          Journal:  Tetrahedron Lett        ISSN: 0040-4039            Impact factor:   2.415


  1 in total

1.  Structural necessity of indole C5-O-substitution of seco-duocarmycin analogs for their cytotoxic activity.

Authors:  Taeyoung Choi; Eunsook Ma
Journal:  Molecules       Date:  2010-11-08       Impact factor: 4.411

  1 in total

北京卡尤迪生物科技股份有限公司 © 2022-2023.