| Literature DB >> 30260068 |
Saeedeh Ebrahimi1,2, Ali Teimoori1,2, Hashem Khanbabaei3, Maryam Tabasi2.
Abstract
The recent development of the Clustered Regularly Interspaced Palindromic Repeat (CRISPR)/CRISPR-associated protein 9 (Cas9) system, a genome editing system, has many potential applications in virology. The possibility of introducing site specific breaks has provided new possibilities to precisely manipulate viral genomics. Here, we provide diagrams to summarize the steps involved in the process. We also systematically review recent applications of the CRISPR/Cas9 system for manipulation of DNA virus genomics and discuss the therapeutic potential of the system to treat viral diseases.Entities:
Keywords: CAS9; CRISPR-CAS system; DNA Viruses; Gene Editing
Mesh:
Substances:
Year: 2018 PMID: 30260068 DOI: 10.1002/rmv.2009
Source DB: PubMed Journal: Rev Med Virol ISSN: 1052-9276 Impact factor: 6.989