Literature DB >> 30259936

Arsenic trioxide preferentially binds to the ring finger protein PML: understanding target selection of the drug.

Cao Kaiming1, Yaping Sheng, Shihui Zheng, Siming Yuan, Guangming Huang, Yangzhong Liu.   

Abstract

Arsenic trioxide (ATO) is used in the clinic for the treatment of acute promyelocytic leukemia by targeting the protein PML. However, many zinc-finger proteins could also be reactive to arsenic in cells. Here we found that ATO preferentially binds to the ring-finger domain of PML in a protein mixture with zinc-finger domains. These results provide the molecular basis of the target selection of ATO in cells.

Entities:  

Mesh：

Substances：

Year:  2018        PMID： 30259936     DOI： 10.1039/c8mt00202a

Source DB:  PubMed          Journal:  Metallomics        ISSN： 1756-5901            Impact factor:   4.526


  8 in total

1.  Zinc controls PML nuclear body formation through regulation of a paralog specific auto-inhibition in SUMO1.

Authors:  Mathieu Lussier-Price; Haytham M Wahba; Xavier H Mascle; Laurent Cappadocia; Veronique Bourdeau; Christina Gagnon; Sebastian Igelmann; Kazuyasu Sakaguchi; Gerardo Ferbeyre; James G Omichinski
Journal:  Nucleic Acids Res       Date:  2022-08-12       Impact factor: 19.160

2.  Beyond Cisplatin: Combination Therapy with Arsenic Trioxide.

Authors:  Ðenana Miodragović; Elden P Swindell; Zohra Sattar Waxali; Abraham Bogachkov; Thomas V O'Halloran
Journal:  Inorganica Chim Acta       Date:  2019-07-24       Impact factor: 3.118

Review 3.  Current Advances of Nanomedicines Delivering Arsenic Trioxide for Enhanced Tumor Therapy.

Authors:  Mengzhen Yu; Yanwen Zhang; Meirong Fang; Shah Jehan; Wenhu Zhou
Journal:  Pharmaceutics       Date:  2022-03-30       Impact factor: 6.525

4.  Arsenicals, the Integrated Stress Response, and Epstein-Barr Virus Lytic Gene Expression.

Authors:  Jaeyeun Lee; Jennifer Stone; Prashant Desai; John G Kosowicz; Jun O Liu; Richard F Ambinder
Journal:  Viruses       Date:  2021-04-30       Impact factor: 5.048

5.  A dual functional ruthenium arene complex induces differentiation and apoptosis of acute promyelocytic leukemia cells.

Authors:  Hai Huang; Kaiming Cao; Yaqiong Kong; Siming Yuan; Hongke Liu; Yucai Wang; Yangzhong Liu
Journal:  Chem Sci       Date:  2019-08-28       Impact factor: 9.825

6.  Arsenoplatin-Ferritin Nanocage: Structure and Cytotoxicity.

Authors:  Giarita Ferraro; Alessandro Pratesi; Damiano Cirri; Paola Imbimbo; Daria Maria Monti; Luigi Messori; Antonello Merlino
Journal:  Int J Mol Sci       Date:  2021-02-13       Impact factor: 5.923

Review 7.  p53 and Zinc: A Malleable Relationship.

Authors:  Jeung-Hoi Ha; Orjola Prela; Darren R Carpizo; Stewart N Loh
Journal:  Front Mol Biosci       Date:  2022-04-13

Review 8.  Arsenic trioxide as a novel anti-glioma drug: a review.

Authors:  Yi Fang; Zhen Zhang
Journal:  Cell Mol Biol Lett       Date:  2020-09-24       Impact factor: 5.787
  8 in total

北京卡尤迪生物科技股份有限公司 © 2022-2023.