Literature DB >> 3025983

Plasma concentrations of angiotensin II and aldosterone during acute left ventricular failure in the dog. Effect of converting enzyme inhibition.

C Hall, B E Karlberg.   

Abstract

Acute left ventricular failure was induced in anesthetized dogs by left coronary embolization. Treatment with the converting enzyme inhibitor enalaprilat (MK-422) was then given. Hemodynamic registrations confirmed the development of left ventricular failure. Plasma concentrations of angiotensin II and aldosterone rose significantly. Treatment with enalaprilat was accompanied by significant reductions in heart preload and afterload and in plasma hormone concentrations.

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Year:  1986        PMID： 3025983     DOI： 10.1007/BF01852104

Source DB:  PubMed          Journal:  Res Exp Med (Berl)        ISSN： 0300-9130


  3 in total

1.  Replacement of salt by a novel potassium- and magnesium-enriched salt alternative improves the cardiovascular effects of ramipril.

Authors:  E M Mervaala; I Paakkari; J Laakso; R Nevala; T M Teräväinen; F Fyhrquist; H Vapaatalo; H Karppanen
Journal:  Br J Pharmacol       Date:  1994-04       Impact factor: 8.739

2.  Ramipril prevents left ventricular hypertrophy with myocardial fibrosis without blood pressure reduction: a one year study in rats.

Authors:  W Linz; J Schaper; G Wiemer; U Albus; B A Schölkens
Journal:  Br J Pharmacol       Date:  1992-12       Impact factor: 8.739

3.  Effects of enalapril and hydrochlorothiazide on the salt-induced cardiac and renal hypertrophy in normotensive rats.

Authors:  E M Mervaala; J Laakso; H Vapaatalo; H Karppanen
Journal:  Naunyn Schmiedebergs Arch Pharmacol       Date:  1994-10       Impact factor: 3.000
  3 in total

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