| Literature DB >> 30259795 |
Lindsey T Saldin1,2, Shil Patel2, Li Zhang2, Luai Huleihel2, George S Hussey2, David G Nascari2, Lina M Quijano2, Xue Li2, Divya Raghu2, Anant K Bajwa1,2, Nicholas G Smith2, Christopher C Chung2, Ashten N Omstead3, Juliann E Kosovec3, Blair A Jobe3, Neill J Turner2,4, Ali H Zaidi3, Stephen F Badylak2,4.
Abstract
IMPACT STATEMENT: Extracellular matrix (ECM) biomaterials were used to treat esophageal cancer patients after cancer resection and promoted regrowth of normal mucosa without recurrence of cancer. The present study investigates the mechanisms by which these materials were successful to prevent the cancerous phenotype. ECM downregulated neoplastic esophageal cell function (proliferation, metabolism), but normal esophageal epithelial cells were unaffected in vitro, and suggests a molecular basis (downregulation of PI3K-Akt, cell cycle) for the promising clinical results. The therapeutic effect appeared to be enhanced using homologous esophageal ECM. This study suggests that ECM can be further investigated to treat cancer patients after resection or in combination with targeted therapy.Entities:
Keywords: cell/matrix interaction; dynamic reciprocity; esophageal cancer; extracellular matrix bioscaffold; gene expression
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Year: 2019 PMID： 30259795 PMCID： PMC6450457 DOI： 10.1089/ten.TEA.2018.0105
Source DB: PubMed Journal: Tissue Eng Part A ISSN： 1937-3341 Impact factor: 3.845