Kuan-Hsuan Chen1,2,3, En-Lin Hsiang2,4, Min-Yen Hsu5,6, Yueh-Ching Chou2,3,7, Tai-Chi Lin1,8, Yuh-Lih Chang2,3, Ching-Yao Tsai4,9, Tzu-Hsuan Li4,5, Lin-Chung Woung4,9, Shih-Jen Chen4,8, Chi-Hsien Peng10, De-Kuang Hwang4,8. 1. Institute of Clinical Medicine, National Yang-Ming University, Taipei, Taiwan. 2. Institute of Pharmacology, National Yang-Ming University, Taipei, Taiwan. 3. Department of Pharmacy, Taipei Veterans General Hospital, Taipei, Taiwan. 4. School of Medicine, National Yang-Ming University, Taipei, Taiwan. 5. Department of Ophthalmology, Chung Shan Medical University Hospital, Taichung, Taiwan. 6. School of Medicine, Chung Shan Medical University, Taichung, Taiwan. 7. School of Pharmacy, Taipei Medical University, Taipei, Taiwan. 8. Department of Ophthalmology, Taipei Veterans General Hospital, Taipei, Taiwan. 9. Department of Ophthalmology, Taipei City Hospital, Taipei, Taiwan. 10. Department of Ophthalmology, Shin Kong Wu Ho-Su Memorial Hospital and Fu-Jen Catholic University, Taipei, Taiwan.
Abstract
PURPOSE: Retina vein occlusion (RVO) is a visual-threatening retinal disease that causes irreversible impaired quality of life. The contribution of oxidative stress behind clinical course of RVO was rarely investigated. The study aimed to measure the serum oxidative biomarker in patients with RVO to investigate further physical response. METHODS: We measured the serum levels of malondialdehyde (MDA), 8-hydroxy-2-deoxyguanosine (8OHdG), Sirutin 1 (SIRT1), peroxisome proliferator- activated receptor gamma (PPAR-r), Peroxisome proliferator-activated receptor gamma coactivator 1-alpha (PGC-1α), orkhead box protein O1 (FOXO1), orkhead box protein O3 (FOXO3), catalase, (SOD) and hydrogen peroxide (H2 O2 ) among 19 patients with cataract as control group and 36 patients with RVO, respectively. RESULTS: The mean MDA, 8OHdG and hydrogen peroxide in the serum were significantly higher in patients with RVO compared with the results in control group subjects. Whereas SIRT1, PPAR-r, PGC-1, FOXO1, FOXO3, catalase and SOD levels in serum were significantly decreased in patients with RVO compared with control group. CONCLUSION: We demonstrated that the serum level of MDA, 8OHdG and hydrogen peroxide is increased in patients with RVO. Among these, the elevation of MDA, 8OHdG and hydrogen peroxide suggests the increasing of serum oxidative stress in RVO patients. All enzymes related reactive oxygen species scavenge were decreased. Thus, focal RVO may increase systemic oxidative stress within serum.
PURPOSE:Retina vein occlusion (RVO) is a visual-threatening retinal disease that causes irreversible impaired quality of life. The contribution of oxidative stress behind clinical course of RVO was rarely investigated. The study aimed to measure the serum oxidative biomarker in patients with RVO to investigate further physical response. METHODS: We measured the serum levels of malondialdehyde (MDA), 8-hydroxy-2-deoxyguanosine (8OHdG), Sirutin 1 (SIRT1), peroxisome proliferator- activated receptor gamma (PPAR-r), Peroxisome proliferator-activated receptor gamma coactivator 1-alpha (PGC-1α), orkhead box protein O1 (FOXO1), orkhead box protein O3 (FOXO3), catalase, (SOD) and hydrogen peroxide (H2 O2 ) among 19 patients with cataract as control group and 36 patients with RVO, respectively. RESULTS: The mean MDA, 8OHdG and hydrogen peroxide in the serum were significantly higher in patients with RVO compared with the results in control group subjects. Whereas SIRT1, PPAR-r, PGC-1, FOXO1, FOXO3, catalase and SOD levels in serum were significantly decreased in patients with RVO compared with control group. CONCLUSION: We demonstrated that the serum level of MDA, 8OHdG and hydrogen peroxide is increased in patients with RVO. Among these, the elevation of MDA, 8OHdG and hydrogen peroxide suggests the increasing of serum oxidative stress in RVOpatients. All enzymes related reactive oxygen species scavenge were decreased. Thus, focal RVO may increase systemic oxidative stress within serum.
Authors: Cemal Orhan; Besir Er; Patrick Brice Defo Deeh; Ahmet Alp Bilgic; Sara Perez Ojalvo; James Richard Komorowski; Kazim Sahin Journal: Biol Trace Elem Res Date: 2021-01-06 Impact factor: 3.738
Authors: Katharina Bell; Vanessa M Beutgen; Stefan Nickels; Katrin Lorenz; Yvonne Scheller; Hisham Elbaz; Tunde Peto; Katharina A Ponto; Andreas Schulz; Philipp S Wild; Thomas Münzel; Karl J Lackner; Irene Schmidtmann; Manfred Beutel; Norbert Pfeiffer; Franz H Grus; Alexander K Schuster Journal: J Ophthalmol Date: 2020-07-29 Impact factor: 1.909