K Uusi-Rasi1, R Patil2,3, S Karinkanta2, K Tokola2, P Kannus2,4,5, C Lamberg-Allardt6, H Sievänen2. 1. The UKK Institute for Health Promotion Research, P.O. Box 30, 33501, Tampere, Finland. kirsti.uusi-rasi@uta.fi. 2. The UKK Institute for Health Promotion Research, P.O. Box 30, 33501, Tampere, Finland. 3. Department of Physiotherapy, Jehangir Hospital, Pune, Maharashtra, 411001, India. 4. Medical School, University of Tampere, Tampere, Finland. 5. Department of Orthopedics and Trauma Surgery, Tampere University Central Hospital, Tampere, Finland. 6. Department of Food and Environmental Sciences, University of Helsinki, Helsinki, Finland.
Abstract
Three hundred eighty-seven home-dwelling older women were divided into quartiles based on mean serum 25-hydroxyvitamin D (S-25(OH)D) levels. The rates of falls and fallers were about 40% lower in the highest S-25(OH)D quartile compared to the lowest despite no differences in physical functioning, suggesting that S-25(OH)D levels may modulate individual fall risk. INTRODUCTION:Vitamin D supplementation of 800 IU did not reduce falls in our previous 2-year vitamin D and exercise RCT in 70-80 year old women. Given large individual variation in individual responses, we assessed here effects of S-25(OH)D levels on fall incidence. METHODS: Irrespective of original group allocation, data from 387 women were explored in quartiles by meanS-25(OH)D levels over 6-24 months; means (SD) were 59.3 (7.2), 74.5 (3.3), 85.7 (3.5), and 105.3 (10.9) nmol/L. Falls were recorded monthly with diaries. Physical functioning and bone density were assessed annually. Negative binomial regression was used to assess incidence rate ratios (IRRs) for falls and Cox-regression to assess hazard ratios (HR) for fallers. Generalized linear models were used to test between-quartile differences in physical functioning and bone density with the lowest quartile as reference. RESULTS: There were 37% fewer falls in the highest quartile, while the two middle quartiles did not differ from reference. The respective IRRs (95% CI) for falls were 0.63 (0.44 to 0.90), 0.78 (0.55 to 1.10), and 0.87 (0.62 to 1.22), indicating lower falls incidence with increasing mean S-25(OH)D levels. There were 42% fewer fallers (HR 0.58; 040 to 0.83) in the highest quartile compared to reference. Physical functioning did not differ between quartiles. CONCLUSIONS:Falls and faller rates were about 40% lower in the highest S-25(OH)D quartile despite similar physical functioning in all quartiles. Prevalent S-25(OH)D levels may influence individual fall risk. Individual responses to vitamin D treatment should be considered in falls prevention.
RCT Entities:
Three hundred eighty-seven home-dwelling older women were divided into quartiles based on mean serum 25-hydroxyvitamin D (S-25(OH)D) levels. The rates of falls and fallers were about 40% lower in the highest S-25(OH)D quartile compared to the lowest despite no differences in physical functioning, suggesting that S-25(OH)D levels may modulate individual fall risk. INTRODUCTION:Vitamin D supplementation of 800 IU did not reduce falls in our previous 2-year vitamin D and exercise RCT in 70-80 year old women. Given large individual variation in individual responses, we assessed here effects of S-25(OH)D levels on fall incidence. METHODS: Irrespective of original group allocation, data from 387 women were explored in quartiles by mean S-25(OH)D levels over 6-24 months; means (SD) were 59.3 (7.2), 74.5 (3.3), 85.7 (3.5), and 105.3 (10.9) nmol/L. Falls were recorded monthly with diaries. Physical functioning and bone density were assessed annually. Negative binomial regression was used to assess incidence rate ratios (IRRs) for falls and Cox-regression to assess hazard ratios (HR) for fallers. Generalized linear models were used to test between-quartile differences in physical functioning and bone density with the lowest quartile as reference. RESULTS: There were 37% fewer falls in the highest quartile, while the two middle quartiles did not differ from reference. The respective IRRs (95% CI) for falls were 0.63 (0.44 to 0.90), 0.78 (0.55 to 1.10), and 0.87 (0.62 to 1.22), indicating lower falls incidence with increasing mean S-25(OH)D levels. There were 42% fewer fallers (HR 0.58; 040 to 0.83) in the highest quartile compared to reference. Physical functioning did not differ between quartiles. CONCLUSIONS: Falls and faller rates were about 40% lower in the highest S-25(OH)D quartile despite similar physical functioning in all quartiles. Prevalent S-25(OH)D levels may influence individual fall risk. Individual responses to vitamin D treatment should be considered in falls prevention.
Entities:
Keywords:
Bone density; Falls prevention; Older women; Physical functioning; Vitamin D
Authors: Kerrie M Sanders; Amanda L Stuart; Elizabeth J Williamson; Julie A Simpson; Mark A Kotowicz; Doris Young; Geoffrey C Nicholson Journal: JAMA Date: 2010-05-12 Impact factor: 56.272
Authors: Heike A Bischoff-Ferrari; Walter C Willett; Endel J Orav; Endel J Oray; Paul Lips; Pierre J Meunier; Ronan A Lyons; Leon Flicker; John Wark; Rebecca D Jackson; Jane A Cauley; Haakon E Meyer; Michael Pfeifer; Kerrie M Sanders; Hannes B Stähelin; Robert Theiler; Bess Dawson-Hughes Journal: N Engl J Med Date: 2012-07-05 Impact factor: 91.245
Authors: Heike A Bischoff-Ferrari; Bess Dawson-Hughes; E John Orav; Hannes B Staehelin; Otto W Meyer; Robert Theiler; Walter Dick; Walter C Willett; Andreas Egli Journal: JAMA Intern Med Date: 2016-02 Impact factor: 21.873
Authors: Ilse S Wicherts; Natasja M van Schoor; A Joan P Boeke; Marjolein Visser; Dorly J H Deeg; Jan Smit; Dirk L Knol; Paul Lips Journal: J Clin Endocrinol Metab Date: 2007-03-06 Impact factor: 5.958
Authors: Michael Schwenk; Andreas Lauenroth; Christian Stock; Raquel Rodriguez Moreno; Peter Oster; Gretl McHugh; Chris Todd; Klaus Hauer Journal: BMC Med Res Methodol Date: 2012-04-17 Impact factor: 4.615
Authors: Gabrielle B Britton; Sid E O'Bryant; Leigh A Johnson; James R Hall; Alcibiades E Villarreal; Diana C Oviedo; Ambar R Pérez-Lao; María B Carreira Journal: Curr Aging Sci Date: 2019