Literature DB >> 30254520

Modeling Pediatric Epilepsy Through iPSC-Based Technologies.

Dina Simkin1, Evangelos Kiskinis2.   

Abstract

In the current review, we discuss the process of modeling pediatric epileptic encephalopathies with a focus on in vitro iPSC-based technologies. We highlight the potential benefits as well as the challenges of these approaches and propose appropriate standards for the field.

Entities:  

Year:  2018        PMID： 30254520      PMCID： PMC6145379          DOI： 10.5698/1535-7597.18.4.240

Source DB:  PubMed          Journal:  Epilepsy Curr        ISSN： 1535-7511            Impact factor:   7.500


  50 in total

1.  Non-cell autonomous effect of glia on motor neurons in an embryonic stem cell-based ALS model.

Authors:  Francesco Paolo Di Giorgio; Monica A Carrasco; Michelle C Siao; Tom Maniatis; Kevin Eggan
Journal:  Nat Neurosci       Date:  2007-04-15       Impact factor: 24.884

2.  Expression and function of KCNQ channels in larval zebrafish.

Authors:  Sally W Chege; Gabriela A Hortopan; Matthew T Dinday; Scott C Baraban
Journal:  Dev Neurobiol       Date:  2012-02       Impact factor: 3.964

3.  Human Astrocyte Maturation Captured in 3D Cerebral Cortical Spheroids Derived from Pluripotent Stem Cells.

Authors:  Steven A Sloan; Spyros Darmanis; Nina Huber; Themasap A Khan; Fikri Birey; Christine Caneda; Richard Reimer; Stephen R Quake; Ben A Barres; Sergiu P Paşca
Journal:  Neuron       Date:  2017-08-16       Impact factor: 17.173

Review 4.  Seizure and epilepsy: studies of seizure disorders in Drosophila.

Authors:  Louise Parker; Iris C Howlett; Zeid M Rusan; Mark A Tanouye
Journal:  Int Rev Neurobiol       Date:  2011       Impact factor: 3.230

5.  Use-Dependent Block of Human Cardiac Sodium Channels by GS967.

Authors:  Franck Potet; Carlos G Vanoye; Alfred L George
Journal:  Mol Pharmacol       Date:  2016-05-02       Impact factor: 4.436

Review 6.  A roadmap for precision medicine in the epilepsies.

Authors: 
Journal:  Lancet Neurol       Date:  2015-09-20       Impact factor: 44.182

7.  Brain-Region-Specific Organoids Using Mini-bioreactors for Modeling ZIKV Exposure.

Authors:  Xuyu Qian; Ha Nam Nguyen; Mingxi M Song; Christopher Hadiono; Sarah C Ogden; Christy Hammack; Bing Yao; Gregory R Hamersky; Fadi Jacob; Chun Zhong; Ki-Jun Yoon; William Jeang; Li Lin; Yujing Li; Jai Thakor; Daniel A Berg; Ce Zhang; Eunchai Kang; Michael Chickering; David Nauen; Cheng-Ying Ho; Zhexing Wen; Kimberly M Christian; Pei-Yong Shi; Brady J Maher; Hao Wu; Peng Jin; Hengli Tang; Hongjun Song; Guo-Li Ming
Journal:  Cell       Date:  2016-04-22       Impact factor: 41.582

Review 8.  Probing disorders of the nervous system using reprogramming approaches.

Authors:  Justin K Ichida; Evangelos Kiskinis
Journal:  EMBO J       Date:  2015-04-29       Impact factor: 11.598

9.  Drug screening in Scn1a zebrafish mutant identifies clemizole as a potential Dravet syndrome treatment.

Authors:  Scott C Baraban; Matthew T Dinday; Gabriela A Hortopan
Journal:  Nat Commun       Date:  2013       Impact factor: 14.919

10.  CRISPR/Cas9 facilitates investigation of neural circuit disease using human iPSCs: mechanism of epilepsy caused by an SCN1A loss-of-function mutation.

Authors:  J Liu; C Gao; W Chen; W Ma; X Li; Y Shi; H Zhang; L Zhang; Y Long; H Xu; X Guo; S Deng; X Yan; D Yu; G Pan; Y Chen; L Lai; W Liao; Z Li
Journal:  Transl Psychiatry       Date:  2016-01-05       Impact factor: 6.222
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  9 in total

Review 1.  Dogs as a Natural Animal Model of Epilepsy.

Authors:  Wolfgang Löscher
Journal:  Front Vet Sci       Date:  2022-06-22

Review 2.  Cerebral Organoids and Antisense Oligonucleotide Therapeutics: Challenges and Opportunities.

Authors:  Jenny Lange; Haiyan Zhou; Amy McTague
Journal:  Front Mol Neurosci       Date:  2022-06-27       Impact factor: 6.261

Review 3.  Screening Platforms for Genetic Epilepsies-Zebrafish, iPSC-Derived Neurons, and Organoids.

Authors:  Aleksandr Shcheglovitov; Randall T Peterson
Journal:  Neurotherapeutics       Date:  2021-09-30       Impact factor: 6.088

Review 4.  Targeting NMDA receptors in neuropsychiatric disorders by drug screening on human neurons derived from pluripotent stem cells.

Authors:  Wenbo Zhang; P Joel Ross; James Ellis; Michael W Salter
Journal:  Transl Psychiatry       Date:  2022-06-09       Impact factor: 7.989

5.  Dyshomeostatic modulation of Ca2+-activated K+ channels in a human neuronal model of KCNQ2 encephalopathy.

Authors:  Dina Simkin; Kelly A Marshall; Carlos G Vanoye; Reshma R Desai; Bernabe I Bustos; Brandon N Piyevsky; Juan A Ortega; Marc Forrest; Gabriella L Robertson; Peter Penzes; Linda C Laux; Steven J Lubbe; John J Millichap; Alfred L George; Evangelos Kiskinis
Journal:  Elife       Date:  2021-02-05       Impact factor: 8.713

Review 6.  Induced pluripotent stem cells for therapy personalization in pediatric patients: Focus on drug-induced adverse events.

Authors:  Elena Genova; Federica Cavion; Marianna Lucafò; Luigina De Leo; Marco Pelin; Gabriele Stocco; Giuliana Decorti
Journal:  World J Stem Cells       Date:  2019-12-26       Impact factor: 5.326

Review 7.  New Insights Into the Role of Aberrant Hippocampal Neurogenesis in Epilepsy.

Authors:  Peng Chen; Fuchao Chen; Yue Wu; Benhong Zhou
Journal:  Front Neurol       Date:  2021-12-15       Impact factor: 4.003

Review 8.  Modeling Epilepsy Using Human Induced Pluripotent Stem Cells-Derived Neuronal Cultures Carrying Mutations in Ion Channels and the Mechanistic Target of Rapamycin Pathway.

Authors:  Octavia Yifang Weng; Yun Li; Lu-Yang Wang
Journal:  Front Mol Neurosci       Date:  2022-03-10       Impact factor: 5.639

Review 9.  Personalized Medicine Using Cutting Edge Technologies for Genetic Epilepsies.

Authors:  Sheila Garcia-Rosa; Bianca de Freitas Brenha; Vinicius Felipe da Rocha; Ernesto Goulart; Bruno Henrique Silva Araujo
Journal:  Curr Neuropharmacol       Date:  2021       Impact factor: 7.363
  9 in total

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